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• W2091632783 abstract "Hemodynamic studies were performed before and after restoration of a normal sinus rhythm in forty-eight patients with chronic atrial fibrillation. Conversion to a sinus mechanism was achieved in twenty-six patients with quinidine and in twenty-two patients with capacitor discharged direct current. In the quinidine-treated group, who were restudied five to ten days after conversion, the mean cardiac index had risen 22 per cent from 2.40 to 2.93 L., the circulation time had decreased from a mean of 17 to 12 seconds, the mean stroke volume had increased 44 per cent from 55 to 79 ml. and the mean arteriovenous oxygen difference had dropped from 5.4 to 4.3 cc. per 100 ml. In the electrically treated group, who were studied serially for 3 hours after conversion, there was a gradual 12 per cent rise in cardiac index from a preconversion mean of 2.36 to 2.65 L. 180 minutes later, accompanied by commensurate improvement in the other hemodynamic parameters. Our data confirm the experimental studies reported in lower animals and man which indicate that a normally positioned atrial systole contributes importantly to ventricular function since restoration of a normal sinus mechanism in patients with chronic atrial fibrillation is followed by a significant increase in cardiac output. The full hemodynamic benefit, however, may not be evident for several hours or days after the return of normal electrical atrial activity." @default.
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• W2091632783 date "1966-08-01" @default.
• W2091632783 modified "2023-10-13" @default.
• W2091632783 title "Effect on cardiac output of conversion from atrial fibrillation to normal sinus mechanism" @default.
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• W2091632783 doi "https://doi.org/10.1016/0002-9343(66)90020-9" @default.
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