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- W2091644923 abstract "In eukaryotic cells, regulated vesicular trafficking is critical for directing protein transport and for recycling and degradation of membrane lipids and proteins. Through carefully regulated transport vesicles, the endomembrane system performs a large and important array of dynamic cellular functions while maintaining the integrity of the cellular membrane system. Genetic studies in yeast Saccharomyces cerevisiae have identified approximately 50 vacuolar protein sorting (VPS) genes involved in vesicle trafficking, and most of these genes are also characterized in mammals. The VPS proteins form distinct functional complexes, which include complexes known as ESCRT, retromer, CORVET, HOPS, GARP, and PI3K-III. Little is known about the orthologs of VPS proteins in insects. Here, with the newly annotated Manduca sexta genome, we carried out genomic comparative analysis of VPS proteins in yeast, humans, and 13 sequenced insect genomes representing the Orders Hymenoptera, Diptera, Hemiptera, Phthiraptera, Lepidoptera, and Coleoptera. Amino acid sequence alignments and domain/motif structure analyses reveal that most of the components of ESCRT, retromer, CORVET, HOPS, GARP, and PI3K-III are evolutionarily conserved across yeast, insects, and humans. However, in contrast to the VPS gene expansions observed in the human genome, only four VPS genes (VPS13, VPS16, VPS33, and VPS37) were expanded in the six insect Orders. Additionally, VPS2 was expanded only in species from Phthiraptera, Lepidoptera, and Coleoptera. These studies provide a baseline for understanding the evolution of vesicular trafficking across yeast, insect, and human genomes, and also provide a basis for further addressing specific functional roles of VPS proteins in insects." @default.
- W2091644923 created "2016-06-24" @default.
- W2091644923 creator A5002900514 @default.
- W2091644923 creator A5039074069 @default.
- W2091644923 date "2015-07-01" @default.
- W2091644923 modified "2023-10-10" @default.
- W2091644923 title "The vacuolar protein sorting genes in insects: A comparative genome view" @default.
- W2091644923 cites W1569110994 @default.
- W2091644923 cites W1768215066 @default.
- W2091644923 cites W1964951207 @default.
- W2091644923 cites W1967591469 @default.
- W2091644923 cites W1968242602 @default.
- W2091644923 cites W1968419204 @default.
- W2091644923 cites W1969889060 @default.
- W2091644923 cites W1973214920 @default.
- W2091644923 cites W1973284660 @default.
- W2091644923 cites W1976074435 @default.
- W2091644923 cites W1976916223 @default.
- W2091644923 cites W1977701732 @default.
- W2091644923 cites W1980798766 @default.
- W2091644923 cites W1981515958 @default.
- W2091644923 cites W1982606786 @default.
- W2091644923 cites W1983379765 @default.
- W2091644923 cites W1987966619 @default.
- W2091644923 cites W1989893248 @default.
- W2091644923 cites W1992721127 @default.
- W2091644923 cites W1993296488 @default.
- W2091644923 cites W1993871755 @default.
- W2091644923 cites W1994683562 @default.
- W2091644923 cites W1995012413 @default.
- W2091644923 cites W1996339481 @default.
- W2091644923 cites W1996675875 @default.
- W2091644923 cites W1997978994 @default.
- W2091644923 cites W1998079639 @default.
- W2091644923 cites W2007647318 @default.
- W2091644923 cites W2009023024 @default.
- W2091644923 cites W2015319588 @default.
- W2091644923 cites W2015614032 @default.
- W2091644923 cites W2016350753 @default.
- W2091644923 cites W2018774226 @default.
- W2091644923 cites W2023962251 @default.
- W2091644923 cites W2024645073 @default.
- W2091644923 cites W2025134311 @default.
- W2091644923 cites W2030769704 @default.
- W2091644923 cites W2030966943 @default.
- W2091644923 cites W2038487590 @default.
- W2091644923 cites W2039592143 @default.
- W2091644923 cites W2039695824 @default.
- W2091644923 cites W2040007466 @default.
- W2091644923 cites W2042722403 @default.
- W2091644923 cites W2043969588 @default.
- W2091644923 cites W2048683930 @default.
- W2091644923 cites W2053957762 @default.
- W2091644923 cites W2055473408 @default.
- W2091644923 cites W2057370954 @default.
- W2091644923 cites W2062047503 @default.
- W2091644923 cites W2063103841 @default.
- W2091644923 cites W2065164168 @default.
- W2091644923 cites W2067665559 @default.
- W2091644923 cites W2069422711 @default.
- W2091644923 cites W2070732930 @default.
- W2091644923 cites W2073022188 @default.
- W2091644923 cites W2074130602 @default.
- W2091644923 cites W2078374647 @default.
- W2091644923 cites W2079319844 @default.
- W2091644923 cites W2079368124 @default.
- W2091644923 cites W2082196715 @default.
- W2091644923 cites W2083480759 @default.
- W2091644923 cites W2088213537 @default.
- W2091644923 cites W2089916390 @default.
- W2091644923 cites W2091861303 @default.
- W2091644923 cites W2093849705 @default.
- W2091644923 cites W2094205174 @default.
- W2091644923 cites W2094452786 @default.
- W2091644923 cites W2099903706 @default.
- W2091644923 cites W2100138389 @default.
- W2091644923 cites W2100779577 @default.
- W2091644923 cites W2101291993 @default.
- W2091644923 cites W2104079020 @default.
- W2091644923 cites W2104969134 @default.
- W2091644923 cites W2107386898 @default.
- W2091644923 cites W2107843919 @default.
- W2091644923 cites W2109180315 @default.
- W2091644923 cites W2109900607 @default.
- W2091644923 cites W2110522042 @default.
- W2091644923 cites W2115778080 @default.
- W2091644923 cites W2115907325 @default.
- W2091644923 cites W2116002414 @default.
- W2091644923 cites W2118091426 @default.
- W2091644923 cites W2119783761 @default.
- W2091644923 cites W2120348985 @default.
- W2091644923 cites W2121633863 @default.
- W2091644923 cites W2122235477 @default.
- W2091644923 cites W2122826962 @default.
- W2091644923 cites W2124818274 @default.
- W2091644923 cites W2125083829 @default.
- W2091644923 cites W2129010183 @default.
- W2091644923 cites W2130691377 @default.