Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091650004> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2091650004 abstract "Ricin B chain incubated at 37 degrees C in the absence of lactose loses its ability to bind the galactose-containing protein, asialofetuin. Circular dichroism analysis of the B chain during thermal denaturation indicates that the loss of galactose-binding ability by the B chain correlates with limited unfolding of the molecule. As a result of this conformational change, disulfide bonds that are shielded from the solvent by the compact folded structure of the B chain become exposed and the chitobiosyl cores of both N-linked oligomannose chains become susceptible to cleavage by endoglycosidases. The heat-denatured B chain does not enhance the toxicity of a ricin A chain-containing rabbit anti-human immunoglobulin (RAHIg-A) to Daudi cells. However, when heat-denatured B chain is coupled to goat anti-rabbit immunoglobulin (GARIg), the resulting immunotoxin, GARIg-hdB, potentiates the killing of RAHIg-A-treated Daudi cells to an extent similar to that of an immunotoxin prepared with GARIg and native B chain. These results indicate that the native, galactose-binding structure of the B chain is not necessary to enhance the cytotoxicity of the cell-reactive A chain immunotoxin (IT-A) and suggests that regions of the B chain exposed by unfolding the molecule may mediate potentiation of cytotoxicity." @default.
- W2091650004 created "2016-06-24" @default.
- W2091650004 creator A5023160506 @default.
- W2091650004 creator A5035275962 @default.
- W2091650004 creator A5068926524 @default.
- W2091650004 creator A5075704410 @default.
- W2091650004 creator A5084475433 @default.
- W2091650004 date "1988-08-01" @default.
- W2091650004 modified "2023-09-24" @default.
- W2091650004 title "Ricin B chain-containing immunotoxins prepared with heat-denatured B chain lacking galactose-binding ability potentiate the cytotoxicity of a cell-reactive ricin A chain immunotoxin" @default.
- W2091650004 cites W1500247723 @default.
- W2091650004 cites W1530321233 @default.
- W2091650004 cites W1586747665 @default.
- W2091650004 cites W1647458656 @default.
- W2091650004 cites W1965461790 @default.
- W2091650004 cites W1974440965 @default.
- W2091650004 cites W1980238668 @default.
- W2091650004 cites W1987766990 @default.
- W2091650004 cites W2043120873 @default.
- W2091650004 cites W2043133764 @default.
- W2091650004 cites W2057293049 @default.
- W2091650004 cites W2061699262 @default.
- W2091650004 cites W2075077207 @default.
- W2091650004 cites W2100837269 @default.
- W2091650004 cites W21065765 @default.
- W2091650004 cites W2133798417 @default.
- W2091650004 cites W2149866422 @default.
- W2091650004 doi "https://doi.org/10.1016/0167-4889(88)90161-9" @default.
- W2091650004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2841982" @default.
- W2091650004 hasPublicationYear "1988" @default.
- W2091650004 type Work @default.
- W2091650004 sameAs 2091650004 @default.
- W2091650004 citedByCount "8" @default.
- W2091650004 crossrefType "journal-article" @default.
- W2091650004 hasAuthorship W2091650004A5023160506 @default.
- W2091650004 hasAuthorship W2091650004A5035275962 @default.
- W2091650004 hasAuthorship W2091650004A5068926524 @default.
- W2091650004 hasAuthorship W2091650004A5075704410 @default.
- W2091650004 hasAuthorship W2091650004A5084475433 @default.
- W2091650004 hasConcept C109316439 @default.
- W2091650004 hasConcept C115085202 @default.
- W2091650004 hasConcept C153911025 @default.
- W2091650004 hasConcept C159654299 @default.
- W2091650004 hasConcept C185592680 @default.
- W2091650004 hasConcept C202751555 @default.
- W2091650004 hasConcept C203014093 @default.
- W2091650004 hasConcept C2777200438 @default.
- W2091650004 hasConcept C2777367657 @default.
- W2091650004 hasConcept C36394416 @default.
- W2091650004 hasConcept C55493867 @default.
- W2091650004 hasConcept C86803240 @default.
- W2091650004 hasConceptScore W2091650004C109316439 @default.
- W2091650004 hasConceptScore W2091650004C115085202 @default.
- W2091650004 hasConceptScore W2091650004C153911025 @default.
- W2091650004 hasConceptScore W2091650004C159654299 @default.
- W2091650004 hasConceptScore W2091650004C185592680 @default.
- W2091650004 hasConceptScore W2091650004C202751555 @default.
- W2091650004 hasConceptScore W2091650004C203014093 @default.
- W2091650004 hasConceptScore W2091650004C2777200438 @default.
- W2091650004 hasConceptScore W2091650004C2777367657 @default.
- W2091650004 hasConceptScore W2091650004C36394416 @default.
- W2091650004 hasConceptScore W2091650004C55493867 @default.
- W2091650004 hasConceptScore W2091650004C86803240 @default.
- W2091650004 hasLocation W20916500041 @default.
- W2091650004 hasLocation W20916500042 @default.
- W2091650004 hasOpenAccess W2091650004 @default.
- W2091650004 hasPrimaryLocation W20916500041 @default.
- W2091650004 hasRelatedWork W141097586 @default.
- W2091650004 hasRelatedWork W1527961726 @default.
- W2091650004 hasRelatedWork W1637019120 @default.
- W2091650004 hasRelatedWork W1976910216 @default.
- W2091650004 hasRelatedWork W2002582818 @default.
- W2091650004 hasRelatedWork W2061619994 @default.
- W2091650004 hasRelatedWork W230369074 @default.
- W2091650004 hasRelatedWork W2411738868 @default.
- W2091650004 hasRelatedWork W2418313328 @default.
- W2091650004 hasRelatedWork W2467276012 @default.
- W2091650004 isParatext "false" @default.
- W2091650004 isRetracted "false" @default.
- W2091650004 magId "2091650004" @default.
- W2091650004 workType "article" @default.