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• W2091651330 abstract "CD8+ T cells have emerged as crucial players in the control of a number of protozoan pathogens, including Trypanosoma cruzi, the agent of human Chagas disease. The recent identification of the dominant targets of T. cruzi-specific T cells has allowed investigators to follow the generation of and document the functionality of T cell responses in both mice and humans. Although slow to develop in the early stages of the infection, T. cruzi-specific CD8+ T cells reach prodigious levels and remain highly functional throughout chronic infections in mice. Following drug-induced cure during either the acute or chronic stage, these immunodominant T cells persist as stable, antigen-independent memory populations. T. cruzi-specific CD8+ T cells in humans are less-well-studied but appear to lose functionality and decline in numbers in these decades-long infections. Changes in the frequency of parasite-specific T cell upon therapeutic treatment in humans may provide a new metric for determining treatment efficacy." @default.
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• W2091651330 date "2009-08-01" @default.
• W2091651330 modified "2023-10-17" @default.
• W2091651330 title "CD8+ T cells in Trypanosoma cruzi infection" @default.
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• W2091651330 doi "https://doi.org/10.1016/j.coi.2009.07.006" @default.
• W2091651330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2735075" @default.
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