FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091660894> ?p ?o ?g. }

• W2091660894 endingPage "375" @default.
• W2091660894 startingPage "360" @default.
• W2091660894 abstract "Semaphorin-3A (Sema3A) is an attractive guidance molecule for cortical apical dendrites. To elucidate the role of Sema3A in hippocampal dendritic formation, we examined the Sema3A expression pattern in the perinatal hippocampal formation and analyzed hippocampal dendrites of the brains from young adult sema3A mutant mice. Sema3A protein was predominantly expressed in the hippocampal plate and the inner marginal zone at the initial period of apical dendritic growth. Neuropilin-1 and plexin-A, the receptor components for Sema3A, were also localized in the same regions. The Golgi impregnation method revealed that in wildtype mice more than 90% of hippocampal CA1 pyramidal neurons extended a single trunk or apical trunks bifurcated in stratum radiatum. Seven percent of the pyramidal neurons showed proximal bifurcation of apical trunks in stratum pyramidale or at the border of the stratum pyramidale and stratum radiatum. In sema3A mutant mice, proximally bifurcated apical dendrites were increased to 32%, while the single apical dendritic pyramidal neurons were decreased. We designate this phenotype in sema3A mutant mice as proximal bifurcation. In the dissociated culture system, approximately half of the hippocampal neurons from wildtype mice resembled pyramidal neurons, which possess a long, thick, and tapered dendrite. In contrast, only 30% of the neurons from sema3A mutants exhibited pyramidal-like morphology. Proximal bifurcation of CA1 pyramidal neurons was also increased in the mutant mice of p35, an activator of cyclin-dependent kinase 5 (Cdk5). Thus, Sema3A may facilitate the initial growth of CA1 apical dendrites via the activation of p35/Cdk5, which may in turn signal hippocampal development." @default.
• W2091660894 created "2016-06-24" @default.
• W2091660894 creator A5021450975 @default.
• W2091660894 creator A5025712353 @default.
• W2091660894 creator A5032171375 @default.
• W2091660894 creator A5036678039 @default.
• W2091660894 creator A5037485998 @default.
• W2091660894 creator A5048426520 @default.
• W2091660894 creator A5066177154 @default.
• W2091660894 creator A5074016785 @default.
• W2091660894 date "2009-10-10" @default.
• W2091660894 modified "2023-10-16" @default.
• W2091660894 title "Increased proximal bifurcation of CA1 pyramidal apical dendrites insema3Amutant mice" @default.
• W2091660894 cites W1521626316 @default.
• W2091660894 cites W1964840560 @default.
• W2091660894 cites W1978146656 @default.
• W2091660894 cites W1987695717 @default.
• W2091660894 cites W1987868279 @default.
• W2091660894 cites W2000762378 @default.
• W2091660894 cites W2015495293 @default.
• W2091660894 cites W2026604158 @default.
• W2091660894 cites W2035174549 @default.
• W2091660894 cites W2038901745 @default.
• W2091660894 cites W2044140229 @default.
• W2091660894 cites W2047166961 @default.
• W2091660894 cites W2048133927 @default.
• W2091660894 cites W2051053924 @default.
• W2091660894 cites W2060240421 @default.
• W2091660894 cites W2064077517 @default.
• W2091660894 cites W2065441543 @default.
• W2091660894 cites W2067961553 @default.
• W2091660894 cites W2068599628 @default.
• W2091660894 cites W2078015875 @default.
• W2091660894 cites W2078209807 @default.
• W2091660894 cites W2084462219 @default.
• W2091660894 cites W2088330078 @default.
• W2091660894 cites W2117767933 @default.
• W2091660894 cites W2119940985 @default.
• W2091660894 cites W2128500531 @default.
• W2091660894 cites W2133592641 @default.
• W2091660894 cites W2155154752 @default.
• W2091660894 cites W2157140132 @default.
• W2091660894 cites W2164261122 @default.
• W2091660894 cites W2169931542 @default.
• W2091660894 doi "https://doi.org/10.1002/cne.22125" @default.
• W2091660894 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19655386" @default.
• W2091660894 hasPublicationYear "2009" @default.
• W2091660894 type Work @default.
• W2091660894 sameAs 2091660894 @default.
• W2091660894 citedByCount "45" @default.
• W2091660894 countsByYear W20916608942012 @default.
• W2091660894 countsByYear W20916608942013 @default.
• W2091660894 countsByYear W20916608942014 @default.
• W2091660894 countsByYear W20916608942015 @default.
• W2091660894 countsByYear W20916608942016 @default.
• W2091660894 countsByYear W20916608942017 @default.
• W2091660894 countsByYear W20916608942018 @default.
• W2091660894 countsByYear W20916608942019 @default.
• W2091660894 countsByYear W20916608942020 @default.
• W2091660894 countsByYear W20916608942021 @default.
• W2091660894 countsByYear W20916608942022 @default.
• W2091660894 crossrefType "journal-article" @default.
• W2091660894 hasAuthorship W2091660894A5021450975 @default.
• W2091660894 hasAuthorship W2091660894A5025712353 @default.
• W2091660894 hasAuthorship W2091660894A5032171375 @default.
• W2091660894 hasAuthorship W2091660894A5036678039 @default.
• W2091660894 hasAuthorship W2091660894A5037485998 @default.
• W2091660894 hasAuthorship W2091660894A5048426520 @default.
• W2091660894 hasAuthorship W2091660894A5066177154 @default.
• W2091660894 hasAuthorship W2091660894A5074016785 @default.
• W2091660894 hasConcept C105702510 @default.
• W2091660894 hasConcept C132538176 @default.
• W2091660894 hasConcept C148762608 @default.
• W2091660894 hasConcept C169760540 @default.
• W2091660894 hasConcept C170493617 @default.
• W2091660894 hasConcept C174884520 @default.
• W2091660894 hasConcept C2524010 @default.
• W2091660894 hasConcept C2776805952 @default.
• W2091660894 hasConcept C2778437258 @default.
• W2091660894 hasConcept C2780681696 @default.
• W2091660894 hasConcept C2781041448 @default.
• W2091660894 hasConcept C33923547 @default.
• W2091660894 hasConcept C55493867 @default.
• W2091660894 hasConcept C84248122 @default.
• W2091660894 hasConcept C86803240 @default.
• W2091660894 hasConcept C95444343 @default.
• W2091660894 hasConceptScore W2091660894C105702510 @default.
• W2091660894 hasConceptScore W2091660894C132538176 @default.
• W2091660894 hasConceptScore W2091660894C148762608 @default.
• W2091660894 hasConceptScore W2091660894C169760540 @default.
• W2091660894 hasConceptScore W2091660894C170493617 @default.
• W2091660894 hasConceptScore W2091660894C174884520 @default.
• W2091660894 hasConceptScore W2091660894C2524010 @default.
• W2091660894 hasConceptScore W2091660894C2776805952 @default.
• W2091660894 hasConceptScore W2091660894C2778437258 @default.
• W2091660894 hasConceptScore W2091660894C2780681696 @default.
• W2091660894 hasConceptScore W2091660894C2781041448 @default.
• W2091660894 hasConceptScore W2091660894C33923547 @default.

• next