FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091668247> ?p ?o ?g. }

• W2091668247 endingPage "483" @default.
• W2091668247 startingPage "477" @default.
• W2091668247 abstract "Background Prostate-specific antigen (PSA) is a serine protease that in serum, is predominantly found complexed to the serine protease inhibitor alpha1-antichymotrypsin (ACT). ACT co-localizes with amyloid plaques in Alzheimer's disease (AD) brain and both PSA and ACT are detectable in cerebrospinal fluid (CSF). Therefore, we aimed to determine whether PSA is produced in the brain and whether PSA and PSA–ACT complex levels in CSF can be used as a biomarker for AD. Methods Levels of ACT and PSA–ACT were determined by sandwich enzyme-linked immunosorbent assay in CSF and serum samples of AD ( n = 16), frontotemporal lobe dementia (FTLD) ( n = 19), mild cognitively impaired (MCI) patients ( n = 19) and controls ( n = 12). Total PSA was determined in a non-competitive immunoassay. Reverse transcriptase–polymerase chain reaction (RT–PCR) for PSA was performed on postmortem hippocampus and temporal cortex specimens from control and AD cases. Results PSA is expressed in the brain, as detected by RT–PCR. PSA and PSA–ACT complexes were detectable in CSF of almost all male and only very few female subjects. The levels of PSA and PSA–ACT complexes in CSF did not differ between AD, FTLD, MCI and control groups. PSA CSF/serum quotients highly correlated with albumin CSF/serum quotients. Furthermore, the hydrodynamic radius of PSA was found to be 3 nm and the theoretical PSA quotient, derived from the Felgenhauer plot, corresponded well with the measured PSA quotient. Conclusions PSA is locally produced in the human brain; however, brain PSA hardly contributes to the CSF levels of PSA. PSA and PSA–ACT levels in CSF are not suitable as a biomarker for AD." @default.
• W2091668247 created "2016-06-24" @default.
• W2091668247 creator A5019631883 @default.
• W2091668247 creator A5025870220 @default.
• W2091668247 creator A5027536677 @default.
• W2091668247 creator A5034654461 @default.
• W2091668247 creator A5053882105 @default.
• W2091668247 creator A5062035305 @default.
• W2091668247 creator A5080558143 @default.
• W2091668247 creator A5091877683 @default.
• W2091668247 date "2009-09-03" @default.
• W2091668247 modified "2023-09-26" @default.
• W2091668247 title "CSF levels of PSA and PSA–ACT complexes in Alzheimer's disease" @default.
• W2091668247 cites W1532754033 @default.
• W2091668247 cites W1845134010 @default.
• W2091668247 cites W1901056825 @default.
• W2091668247 cites W1987368604 @default.
• W2091668247 cites W1991169858 @default.
• W2091668247 cites W1997501760 @default.
• W2091668247 cites W2003569879 @default.
• W2091668247 cites W2010474929 @default.
• W2091668247 cites W2011824425 @default.
• W2091668247 cites W2017512075 @default.
• W2091668247 cites W2037181104 @default.
• W2091668247 cites W2037219882 @default.
• W2091668247 cites W2039428198 @default.
• W2091668247 cites W2044315113 @default.
• W2091668247 cites W2044991634 @default.
• W2091668247 cites W2049588693 @default.
• W2091668247 cites W2052742260 @default.
• W2091668247 cites W2054126953 @default.
• W2091668247 cites W2055467972 @default.
• W2091668247 cites W2065496524 @default.
• W2091668247 cites W2075182032 @default.
• W2091668247 cites W2075211765 @default.
• W2091668247 cites W2077836310 @default.
• W2091668247 cites W2078280064 @default.
• W2091668247 cites W2086335867 @default.
• W2091668247 cites W2102948567 @default.
• W2091668247 cites W2104932745 @default.
• W2091668247 cites W2116784956 @default.
• W2091668247 cites W2131128702 @default.
• W2091668247 cites W2139032756 @default.
• W2091668247 cites W2152117362 @default.
• W2091668247 cites W2163324449 @default.
• W2091668247 cites W2167754585 @default.
• W2091668247 cites W2402900244 @default.
• W2091668247 cites W2755169970 @default.
• W2091668247 cites W4300606042 @default.
• W2091668247 doi "https://doi.org/10.1258/acb.2009.009130" @default.
• W2091668247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19729499" @default.
• W2091668247 hasPublicationYear "2009" @default.
• W2091668247 type Work @default.
• W2091668247 sameAs 2091668247 @default.
• W2091668247 citedByCount "10" @default.
• W2091668247 countsByYear W20916682472012 @default.
• W2091668247 countsByYear W20916682472014 @default.
• W2091668247 countsByYear W20916682472015 @default.
• W2091668247 countsByYear W20916682472017 @default.
• W2091668247 countsByYear W20916682472019 @default.
• W2091668247 countsByYear W20916682472022 @default.
• W2091668247 crossrefType "journal-article" @default.
• W2091668247 hasAuthorship W2091668247A5019631883 @default.
• W2091668247 hasAuthorship W2091668247A5025870220 @default.
• W2091668247 hasAuthorship W2091668247A5027536677 @default.
• W2091668247 hasAuthorship W2091668247A5034654461 @default.
• W2091668247 hasAuthorship W2091668247A5053882105 @default.
• W2091668247 hasAuthorship W2091668247A5062035305 @default.
• W2091668247 hasAuthorship W2091668247A5080558143 @default.
• W2091668247 hasAuthorship W2091668247A5091877683 @default.
• W2091668247 hasBestOaLocation W20916682471 @default.
• W2091668247 hasConcept C121608353 @default.
• W2091668247 hasConcept C126322002 @default.
• W2091668247 hasConcept C134018914 @default.
• W2091668247 hasConcept C147483822 @default.
• W2091668247 hasConcept C159654299 @default.
• W2091668247 hasConcept C185592680 @default.
• W2091668247 hasConcept C203014093 @default.
• W2091668247 hasConcept C2776235491 @default.
• W2091668247 hasConcept C2779651940 @default.
• W2091668247 hasConcept C2780420688 @default.
• W2091668247 hasConcept C2781406297 @default.
• W2091668247 hasConcept C71924100 @default.
• W2091668247 hasConceptScore W2091668247C121608353 @default.
• W2091668247 hasConceptScore W2091668247C126322002 @default.
• W2091668247 hasConceptScore W2091668247C134018914 @default.
• W2091668247 hasConceptScore W2091668247C147483822 @default.
• W2091668247 hasConceptScore W2091668247C159654299 @default.
• W2091668247 hasConceptScore W2091668247C185592680 @default.
• W2091668247 hasConceptScore W2091668247C203014093 @default.
• W2091668247 hasConceptScore W2091668247C2776235491 @default.
• W2091668247 hasConceptScore W2091668247C2779651940 @default.
• W2091668247 hasConceptScore W2091668247C2780420688 @default.
• W2091668247 hasConceptScore W2091668247C2781406297 @default.
• W2091668247 hasConceptScore W2091668247C71924100 @default.
• W2091668247 hasIssue "6" @default.
• W2091668247 hasLocation W20916682471 @default.
• W2091668247 hasLocation W20916682472 @default.

• next