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- W2091674154 abstract "Objective: To investigate the response of HIV-associated severe thrombocytopenia (STP) to highly active antiretroviral therapy (HAART) including protease-inhibitors. Methods: In this retrospective study, 15 patients with HIV-associated STP (platelet count < 50×109/l), mostly antiretroviral experienced (13/15), underwent HAART for at least 6 months (median 21; range 6–41 months) during which the platelet (PLT) count and plasmatic HIV-RNA were monitored. The PLT response was compared to that observed in 19 patients previously treated with zidovudine (AZT) monotherapy. Results: HAART induced a significant increase in the PLT count (χ2=10.53,P =0.01) within the third month which was sustained up to the sixth month of therapy. No STP relapse was observed among eight PLT responders followed for longer than 6 months (median 27; range 7–41 months). The PLT increase after HAART was similar to that observed with AZT monotherapy, but a greater number of HAART patients were antiretroviral-experienced. HAART determined a PLT response in 10/13 subjects whose thrombocytopenia had not improved after previous AZT monotherapy. After 6 months of HAART, a complete platelet response occurred more frequently in patients with undetectable plasma HIV-RNA levels (P=0.01). Conclusions: HAART induces a sustained PLT response in HIV-associated STP, even in antiretroviral-experiencedsubjects and in those with AZT-resistant thrombocytopenia. An undetectable plasma HIV viraemia induced by HAART is necessary for STP recovery." @default.
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- W2091674154 date "2001-07-01" @default.
- W2091674154 modified "2023-09-27" @default.
- W2091674154 title "Response of Severe HIV-Associated Thrombocytopenia to Highly Active Antiretroviral Therapy Including Protease Inhibitors" @default.
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- W2091674154 doi "https://doi.org/10.1053/jinf.2001.0833" @default.
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