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• W2091679945 abstract "A great deal of information on the molecular heterogeneity of hepatitis C virus (HCV) has been achieved since its discovery in 1989. However, little is known about the clinical significance of these variations. Based on the degree of sequence variation, HCV has been classified into six major groups or types, differing by 31-34% at the nucleotide level over the entire virus genome. Each type is divided into several subtypes that differ by 20-23% in nucleotide sequence. Viruses within the same subtype are up to 10% divergent and, within infected individuals, vary by up to 1.5%. Genotype distributions are not homogeneous around the world and may reflect both historical and recent parenteral routes of transmission. The clinical implication of these genomic variations are not yet fully elucidated: genotype 1b has been associated with end-stage liver disease, including liver cirrhosis and hepatocellular carcinoma, but this finding might rather reflect its earlier introduction to the populations studied. Consistent evidence exists that types 2 and 3 have a higher response rate to interferon treatment than type 1, although the interplay between genotype and viral load in determining the response is still unclear. Immunohistochemical studies indicate a stronger activation of the endogenous interferon system in the liver of patients infected with type 1 compared to those infected with types 2 and 3, explaining, at least in part, its low responsiveness to exogenous interferon treatment. Biological, sequence-dependent variations of genotypes have been poorly investigated to date, but differential efficiency of translation activity of the 5' non-coding region has been reported. The availability of in vitro systems for evaluating pathogenetic aspects and neutralization mechanisms will improve the present knowledge on this world-wide infectious disease and on the clinical usefulness of distinguishing between genotypes." @default.
• W2091679945 created "2016-06-24" @default.
• W2091679945 creator A5004773206 @default.
• W2091679945 creator A5082252071 @default.
• W2091679945 date "1996-07-01" @default.
• W2091679945 modified "2023-09-25" @default.
• W2091679945 title "Heterogeneity of hepatitis C virus" @default.
• W2091679945 cites W1559533842 @default.
• W2091679945 cites W1602928637 @default.
• W2091679945 cites W1654040128 @default.
• W2091679945 cites W1656291587 @default.
• W2091679945 cites W173236885 @default.
• W2091679945 cites W1763817602 @default.
• W2091679945 cites W1793615211 @default.
• W2091679945 cites W1812270488 @default.
• W2091679945 cites W1836032532 @default.
• W2091679945 cites W1914838920 @default.
• W2091679945 cites W1956249391 @default.
• W2091679945 cites W1958647255 @default.
• W2091679945 cites W1965333943 @default.
• W2091679945 cites W1971565351 @default.
• W2091679945 cites W1972208581 @default.
• W2091679945 cites W1977948037 @default.
• W2091679945 cites W1979196135 @default.
• W2091679945 cites W1982554992 @default.
• W2091679945 cites W1983264742 @default.
• W2091679945 cites W1987932102 @default.
• W2091679945 cites W1989186373 @default.
• W2091679945 cites W1997368021 @default.
• W2091679945 cites W1999487724 @default.
• W2091679945 cites W2006251590 @default.
• W2091679945 cites W2008849878 @default.
• W2091679945 cites W2015436258 @default.
• W2091679945 cites W2019059456 @default.
• W2091679945 cites W2020730605 @default.
• W2091679945 cites W2024707990 @default.
• W2091679945 cites W2024871385 @default.
• W2091679945 cites W2027252289 @default.
• W2091679945 cites W2031636658 @default.
• W2091679945 cites W2032606474 @default.
• W2091679945 cites W2033199408 @default.
• W2091679945 cites W2040852997 @default.
• W2091679945 cites W2045839792 @default.
• W2091679945 cites W2053370422 @default.
• W2091679945 cites W2055223108 @default.
• W2091679945 cites W2055593260 @default.
• W2091679945 cites W2055601327 @default.
• W2091679945 cites W2056022134 @default.
• W2091679945 cites W2056888338 @default.
• W2091679945 cites W2057381677 @default.
• W2091679945 cites W2059372215 @default.
• W2091679945 cites W2066804172 @default.
• W2091679945 cites W2066849959 @default.
• W2091679945 cites W2077535583 @default.
• W2091679945 cites W2087924794 @default.
• W2091679945 cites W2091624333 @default.
• W2091679945 cites W2098232111 @default.
• W2091679945 cites W2099536639 @default.
• W2091679945 cites W2100572023 @default.
• W2091679945 cites W2100848779 @default.
• W2091679945 cites W2102693570 @default.
• W2091679945 cites W2107414185 @default.
• W2091679945 cites W2108222646 @default.
• W2091679945 cites W2109124959 @default.
• W2091679945 cites W2110309669 @default.
• W2091679945 cites W2110666566 @default.
• W2091679945 cites W2111424027 @default.
• W2091679945 cites W2117851049 @default.
• W2091679945 cites W2118047427 @default.
• W2091679945 cites W2121395299 @default.
• W2091679945 cites W2127869931 @default.
• W2091679945 cites W2132284948 @default.
• W2091679945 cites W2132378391 @default.
• W2091679945 cites W2132608906 @default.
• W2091679945 cites W2137059433 @default.
• W2091679945 cites W2137880935 @default.
• W2091679945 cites W2139683822 @default.
• W2091679945 cites W2145054768 @default.
• W2091679945 cites W2146091571 @default.
• W2091679945 cites W2149127345 @default.
• W2091679945 cites W2150983148 @default.
• W2091679945 cites W2154168388 @default.
• W2091679945 cites W2155562422 @default.
• W2091679945 cites W2160015874 @default.
• W2091679945 cites W2163692778 @default.
• W2091679945 cites W2163831028 @default.
• W2091679945 cites W2164206153 @default.
• W2091679945 cites W2164218288 @default.
• W2091679945 cites W2170516798 @default.
• W2091679945 cites W2171130884 @default.
• W2091679945 cites W2324539587 @default.
• W2091679945 cites W2327804273 @default.
• W2091679945 cites W2335845212 @default.
• W2091679945 cites W2425774172 @default.
• W2091679945 doi "https://doi.org/10.1016/s0950-3528(96)90005-6" @default.
• W2091679945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8864032" @default.
• W2091679945 hasPublicationYear "1996" @default.
• W2091679945 type Work @default.

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