Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091690889> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2091690889 endingPage "290" @default.
- W2091690889 startingPage "281" @default.
- W2091690889 abstract "This multicenter study evaluated the efficacy and safety of simvastatin in patients with primary hypercholesterolemia and in patients with hypercholesterolemia associated with type II diabetes who were being treated with diet or oral antidiabetic agents. The metabolic control of diabetes during drug treatment was also evaluated. Of 90 patients from seven centers, 88 (48 nondiabetic and 40 diabetic) patients completed the study; 2 patients dropped out for reasons other than drug-related adverse events. Patients were admitted to the study if their total cholesterol was ⩾250 mg/dl, low-density lipoprotein (LDL) cholesterol was between 160 to 350 mg/dl, and total triglycerides were <350 mg/dl. Patients followed an isocaloric diet during the entire trial. After a 4-week placebo period, treatment with simvastatin was started at 10 mg/day; the daily dose was increased to 20 mg after 6 weeks if the total cholesterol values were still >200 mg/dl and again from 20 to 40 mg after 12 or 18 weeks if the goal cholesterol value (<200 mg/dl) was not achieved; active drug therapy lasted 24 weeks. At the end of the treatment, compared with baseline, total and LDL cholesterol decreased by 29.7% and 39.1%, respectively, in the patients with primary hypercholesterolemia (mean daily dose, 30.2 mg) and by 30.3% and 42.8%, respectively, in type II diabetic patients (mean daily dose, 21.1. mg). A significant increase in high-density lipoprotein cholesterol was observed in both groups (9.3% in nondiabetic and 11.2% in diabetic patients). Safety parameters did not vary significantly during the trial; side effects were mild and rare. No variations in lens opacities were observed during the study. In diabetic subjects, mean fasting and postprandial glucose, as well as hemoglobin A1c, did not change during the trial. Simvastatin is an effective and safe drug not only for the treatment of primary hypercholesterolemia but also for the treatment of hypercholesterolemia associated with type II diabetes." @default.
- W2091690889 created "2016-06-24" @default.
- W2091690889 creator A5045615128 @default.
- W2091690889 creator A5050809035 @default.
- W2091690889 creator A5055120715 @default.
- W2091690889 creator A5057717851 @default.
- W2091690889 creator A5063306885 @default.
- W2091690889 creator A5079551205 @default.
- W2091690889 creator A5079798693 @default.
- W2091690889 creator A5080872000 @default.
- W2091690889 creator A5088139219 @default.
- W2091690889 creator A5089200243 @default.
- W2091690889 date "1992-08-01" @default.
- W2091690889 modified "2023-09-27" @default.
- W2091690889 title "Efficacy and safety of simvastatin for the treatment of hypercholesterolemia in patients with and without type II diabetes" @default.
- W2091690889 cites W1860487341 @default.
- W2091690889 cites W1946263363 @default.
- W2091690889 cites W2005894959 @default.
- W2091690889 cites W2010042478 @default.
- W2091690889 cites W2020719752 @default.
- W2091690889 cites W2046547711 @default.
- W2091690889 cites W2094856121 @default.
- W2091690889 cites W2115487182 @default.
- W2091690889 cites W2116404316 @default.
- W2091690889 cites W2118567710 @default.
- W2091690889 cites W2120870247 @default.
- W2091690889 cites W2154774609 @default.
- W2091690889 cites W2157076196 @default.
- W2091690889 cites W2313982241 @default.
- W2091690889 doi "https://doi.org/10.1016/s0011-393x(05)80479-5" @default.
- W2091690889 hasPublicationYear "1992" @default.
- W2091690889 type Work @default.
- W2091690889 sameAs 2091690889 @default.
- W2091690889 citedByCount "5" @default.
- W2091690889 crossrefType "journal-article" @default.
- W2091690889 hasAuthorship W2091690889A5045615128 @default.
- W2091690889 hasAuthorship W2091690889A5050809035 @default.
- W2091690889 hasAuthorship W2091690889A5055120715 @default.
- W2091690889 hasAuthorship W2091690889A5057717851 @default.
- W2091690889 hasAuthorship W2091690889A5063306885 @default.
- W2091690889 hasAuthorship W2091690889A5079551205 @default.
- W2091690889 hasAuthorship W2091690889A5079798693 @default.
- W2091690889 hasAuthorship W2091690889A5080872000 @default.
- W2091690889 hasAuthorship W2091690889A5088139219 @default.
- W2091690889 hasAuthorship W2091690889A5089200243 @default.
- W2091690889 hasConcept C126322002 @default.
- W2091690889 hasConcept C134018914 @default.
- W2091690889 hasConcept C142724271 @default.
- W2091690889 hasConcept C197934379 @default.
- W2091690889 hasConcept C204787440 @default.
- W2091690889 hasConcept C27081682 @default.
- W2091690889 hasConcept C2776329913 @default.
- W2091690889 hasConcept C2777180221 @default.
- W2091690889 hasConcept C2778163477 @default.
- W2091690889 hasConcept C555293320 @default.
- W2091690889 hasConcept C71924100 @default.
- W2091690889 hasConcept C90924648 @default.
- W2091690889 hasConceptScore W2091690889C126322002 @default.
- W2091690889 hasConceptScore W2091690889C134018914 @default.
- W2091690889 hasConceptScore W2091690889C142724271 @default.
- W2091690889 hasConceptScore W2091690889C197934379 @default.
- W2091690889 hasConceptScore W2091690889C204787440 @default.
- W2091690889 hasConceptScore W2091690889C27081682 @default.
- W2091690889 hasConceptScore W2091690889C2776329913 @default.
- W2091690889 hasConceptScore W2091690889C2777180221 @default.
- W2091690889 hasConceptScore W2091690889C2778163477 @default.
- W2091690889 hasConceptScore W2091690889C555293320 @default.
- W2091690889 hasConceptScore W2091690889C71924100 @default.
- W2091690889 hasConceptScore W2091690889C90924648 @default.
- W2091690889 hasIssue "2" @default.
- W2091690889 hasLocation W20916908891 @default.
- W2091690889 hasOpenAccess W2091690889 @default.
- W2091690889 hasPrimaryLocation W20916908891 @default.
- W2091690889 hasRelatedWork W1966504330 @default.
- W2091690889 hasRelatedWork W1974041167 @default.
- W2091690889 hasRelatedWork W1974808961 @default.
- W2091690889 hasRelatedWork W1979139803 @default.
- W2091690889 hasRelatedWork W2035331946 @default.
- W2091690889 hasRelatedWork W2037631372 @default.
- W2091690889 hasRelatedWork W2040058909 @default.
- W2091690889 hasRelatedWork W2050245455 @default.
- W2091690889 hasRelatedWork W2132898409 @default.
- W2091690889 hasRelatedWork W2748952813 @default.
- W2091690889 hasVolume "52" @default.
- W2091690889 isParatext "false" @default.
- W2091690889 isRetracted "false" @default.
- W2091690889 magId "2091690889" @default.
- W2091690889 workType "article" @default.