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• W2091709065 startingPage "3357" @default.
• W2091709065 abstract "Complement receptor 1 (CR1, CD35) and complement receptor 2 (CR2, CD21) have been implicated as regulators of B-cell activation. We explored the role of these receptors in the development of humoral immunity by generating CR1- and CR2-deficient mice using gene-targeting techniques. These mice have normal basal levels of IgM and of IgG isotypes. B- and T-cell development are overtly normal. Nevertheless, B-cell responses to low and high doses of a T-cell-dependent antigen are impaired with decreased titers of antigen-specific IgM and IgG isotypes. This defect is not complete because there is still partial activation of B lymphocytes during the primary immune response, with generation of splenic germinal centers and a detectable, although reduced, secondary antibody response. These data suggest that certain T-dependent antigens manifest an absolute dependence on complement receptors for the initiation of a normally robust immune response." @default.
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• W2091709065 date "1996-04-16" @default.
• W2091709065 modified "2023-09-28" @default.
• W2091709065 title "Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2." @default.
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• W2091709065 doi "https://doi.org/10.1073/pnas.93.8.3357" @default.
• W2091709065 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/39612" @default.
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