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• W2091717815 abstract "FK506 is a powerful immunosuppressive drug currently in use that inhibits the activation of several transcription factors (nuclear factor (NF)-AT and NF-kappaB) critical for T cell activation. We show here that, contrary to the situation in T cells, FK506 activates transcription factor NF-kappaB in nonlymphoid cells such as fibroblasts and renal mesangial cells. We further show that FK506 induces NF-kappaB-regulated IL-6 production in vitro and in vivo, in particular in kidney. IL-6 has been shown previously to produce renal abnormalities in vivo, such as mesangioproliferative glomerulonephritis. Similar renal abnormalities were also observed in FK506-treated animals. These results thus suggest a causal relationship between FK506-induced NF-kappaB activation/IL-6 production and some of FK506-induced renal abnormalities." @default.
• W2091717815 created "2016-06-24" @default.
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• W2091717815 date "1996-06-01" @default.
• W2091717815 modified "2023-09-24" @default.
• W2091717815 title "Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy." @default.
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• W2091717815 doi "https://doi.org/10.1172/jci118690" @default.
• W2091717815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507328" @default.
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