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- W2091723184 abstract "The relation of the structure of a number of newly synthesized phosphate esters to their inhibitory activity against trypsin, chymotrypsin, ‘true’ cholinesterase and C′ia has been studied. The rate of the reaction of these four enzymes with a number of ethyl α-acetoxybutylphosphonates in which different substituted phenols serve as the leaving group, X, varies with the strength of the PX bond. The presence of an acetoxy, methoxy or carbethoxy group on the α-carbon of the alkyl chain of p-nitrophenyl ethyl alkylphosphonates or p-nitrophenyl ethyl phenylalkylphosphonates specifically depresses the anti-cholinesterase activity of the phosphonate. Differences in reactivity of p-nitrophenyl ethyl i-naphthylmethylenephosphonate and the corresponding 2-naphthylmethylenephosphonate were noted. The presence of an amino group on the terminal carbon of p-nitrophenyl ethyl pentylphosphonate and p-nitrophenyl ethyl hexylphosphate greatly enhances their anti-trypsin and anti-C′ia activity, but depresses their ability to inactivate chymotrypsin." @default.
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- W2091723184 date "1967-10-01" @default.
- W2091723184 modified "2023-09-23" @default.
- W2091723184 title "The relationship of the structure of phosphonate esters to their ability to inhibit chymotrypsin, trypsin, acetylcholinesterase and C′ia" @default.
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- W2091723184 doi "https://doi.org/10.1016/0005-2795(67)90407-2" @default.
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