FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091723832> ?p ?o ?g. }

• W2091723832 endingPage "172" @default.
• W2091723832 startingPage "165" @default.
• W2091723832 abstract "Evidence suggests that epidermal growth factor receptor (EGFR)-activation status may better predict the clinical behaviour of colon cancers than does EGFR expression. However, the prognostic effect of phospho-EGFR in primary colon cancer remains undefined. Phospho-EGFR (Tyr-1173) and EGFR expression were analysed by immunohistochemistry (IHC) in tissue microarrays of TNM stage II and III colon cancers from completed adjuvant therapy trials (n=388). Staining intensity was scored and correlated with clinicopathological variables, DNA mismatch repair (MMR) status, rates of cell proliferation (Ki-67), apoptosis (caspase-3), and patient survival. Phospho-EGFR expression was detected in 157 of 388 (40%) tumours, whereas EGFR was found in 214 of 361 (59%). Although phospho-EGFR was unrelated to clinicopathological variables, strong EGFR intensity was associated with higher tumour stage (P=0.03). Tumours overexpressing EGFR (P=0.0002) or phospho-EGFR (P=0.015) showed increased Ki-67, but not caspase-3 expression. Phospho-EGFR was not prognostic. EGFR intensity was associated with worse disease-free survival (DFS) (hazard ratio (HR): 1.21 (1.03, 1.41); P=0.019) and overall survival (OS) (HR: 1.19 (1.02, 1.39); P=0.028). Tumours expressing both EGFR and phospho-EGFR had similar survival as EGFR alone. Stage and lymph node number were prognostic for DFS and OS, and histological grade for OS. EGFR was an independent predictor of DFS (P=0.042) after adjustment for stage, histological grade, age, and MMR status. Phospho-EGFR and EGFR expression were associated with tumour cell hyperproliferation. Phospho-EGFR was not prognostic, whereas increased EGFR intensity was independently associated with poor DFS." @default.
• W2091723832 created "2016-06-24" @default.
• W2091723832 creator A5008026182 @default.
• W2091723832 creator A5017412574 @default.
• W2091723832 creator A5035059868 @default.
• W2091723832 creator A5049580044 @default.
• W2091723832 creator A5060306466 @default.
• W2091723832 creator A5062302578 @default.
• W2091723832 creator A5063367975 @default.
• W2091723832 creator A5069073626 @default.
• W2091723832 date "2009-12-08" @default.
• W2091723832 modified "2023-10-18" @default.
• W2091723832 title "Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status" @default.
• W2091723832 cites W1672309274 @default.
• W2091723832 cites W1964321121 @default.
• W2091723832 cites W1966714873 @default.
• W2091723832 cites W1971532948 @default.
• W2091723832 cites W1975561305 @default.
• W2091723832 cites W1992060131 @default.
• W2091723832 cites W1995819860 @default.
• W2091723832 cites W1997561975 @default.
• W2091723832 cites W2004140222 @default.
• W2091723832 cites W2004879613 @default.
• W2091723832 cites W2017214707 @default.
• W2091723832 cites W2018009295 @default.
• W2091723832 cites W2029813057 @default.
• W2091723832 cites W2043696829 @default.
• W2091723832 cites W2043804044 @default.
• W2091723832 cites W2057811812 @default.
• W2091723832 cites W2074023677 @default.
• W2091723832 cites W2076932525 @default.
• W2091723832 cites W2077366285 @default.
• W2091723832 cites W2082130863 @default.
• W2091723832 cites W2084203125 @default.
• W2091723832 cites W2097121246 @default.
• W2091723832 cites W2098895289 @default.
• W2091723832 cites W2101333644 @default.
• W2091723832 cites W2102229790 @default.
• W2091723832 cites W2105763574 @default.
• W2091723832 cites W2114149902 @default.
• W2091723832 cites W2116246337 @default.
• W2091723832 cites W2117849323 @default.
• W2091723832 cites W2121043575 @default.
• W2091723832 cites W2121697185 @default.
• W2091723832 cites W2127951115 @default.
• W2091723832 cites W2129432386 @default.
• W2091723832 cites W2133671622 @default.
• W2091723832 cites W2134739287 @default.
• W2091723832 cites W2136089061 @default.
• W2091723832 cites W2139276825 @default.
• W2091723832 cites W2150132200 @default.
• W2091723832 cites W2151798039 @default.
• W2091723832 cites W2153164684 @default.
• W2091723832 cites W2158863975 @default.
• W2091723832 cites W2159082332 @default.
• W2091723832 cites W2161821474 @default.
• W2091723832 cites W2169947883 @default.
• W2091723832 cites W3016113118 @default.
• W2091723832 doi "https://doi.org/10.1038/sj.bjc.6605473" @default.
• W2091723832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2813748" @default.
• W2091723832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19997103" @default.
• W2091723832 hasPublicationYear "2009" @default.
• W2091723832 type Work @default.
• W2091723832 sameAs 2091723832 @default.
• W2091723832 citedByCount "76" @default.
• W2091723832 countsByYear W20917238322012 @default.
• W2091723832 countsByYear W20917238322013 @default.
• W2091723832 countsByYear W20917238322014 @default.
• W2091723832 countsByYear W20917238322015 @default.
• W2091723832 countsByYear W20917238322016 @default.
• W2091723832 countsByYear W20917238322017 @default.
• W2091723832 countsByYear W20917238322018 @default.
• W2091723832 countsByYear W20917238322019 @default.
• W2091723832 countsByYear W20917238322020 @default.
• W2091723832 countsByYear W20917238322021 @default.
• W2091723832 countsByYear W20917238322022 @default.
• W2091723832 countsByYear W20917238322023 @default.
• W2091723832 crossrefType "journal-article" @default.
• W2091723832 hasAuthorship W2091723832A5008026182 @default.
• W2091723832 hasAuthorship W2091723832A5017412574 @default.
• W2091723832 hasAuthorship W2091723832A5035059868 @default.
• W2091723832 hasAuthorship W2091723832A5049580044 @default.
• W2091723832 hasAuthorship W2091723832A5060306466 @default.
• W2091723832 hasAuthorship W2091723832A5062302578 @default.
• W2091723832 hasAuthorship W2091723832A5063367975 @default.
• W2091723832 hasAuthorship W2091723832A5069073626 @default.
• W2091723832 hasBestOaLocation W20917238321 @default.
• W2091723832 hasConcept C121608353 @default.
• W2091723832 hasConcept C126322002 @default.
• W2091723832 hasConcept C142724271 @default.
• W2091723832 hasConcept C143998085 @default.
• W2091723832 hasConcept C146357865 @default.
• W2091723832 hasConcept C151730666 @default.
• W2091723832 hasConcept C193270364 @default.
• W2091723832 hasConcept C204232928 @default.
• W2091723832 hasConcept C207103383 @default.
• W2091723832 hasConcept C2779438470 @default.
• W2091723832 hasConcept C2780849966 @default.

• next