FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091726345> ?p ?o ?g. }

• W2091726345 endingPage "1126" @default.
• W2091726345 startingPage "1113" @default.
• W2091726345 abstract "The current study examined whether adolescent rats are more vulnerable than adult rats to the lasting adverse effects of cannabinoid exposure on brain and behavior. Male Wistar rats were repeatedly exposed to Delta-9-tetrahydrocannabinol (Delta(9)-THC, 5 mg/kg i.p.) in a place-conditioning paradigm during either the adolescent (post-natal day 28+) or adult (post-natal day 60+) developmental stages. Adult rats avoided a Delta(9)-THC-paired environment after either four or eight pairings and this avoidance persisted for at least 16 days following the final Delta(9)-THC injection. In contrast, adolescent rats showed no significant place aversion. Adult Delta(9)-THC-treated rats produced more vocalizations than adolescent rats when handled during the intoxicated state, also suggesting greater drug-induced aversion. After a 10-15 day washout, both adult and adolescent Delta(9)-THC pretreated rats showed decreased social interaction, while only Delta(9)-THC pretreated adolescent rats showed significantly impaired object recognition memory. Seventeen days following their last Delta(9)-THC injection, rats were euthanased and hippocampal tissue processed using two-dimensional gel electrophoresis proteomics. There was no evidence of residual Delta(9)-THC being present in blood at this time. Proteomic analysis uncovered 27 proteins, many involved in regulating oxidative stress/mitochondrial functioning and cytoarchitecture, which were differentially expressed in adolescent Delta(9)-THC pretreated rats relative to adolescent controls. In adults, only 10 hippocampal proteins were differentially expressed in Delta(9)-THC compared to vehicle-pretreated controls. Overall these findings suggest that adolescent rats find repeated Delta(9)-THC exposure less aversive than adults, but that cannabinoid exposure causes greater lasting memory deficits and hippocampal alterations in adolescent than adult rats." @default.
• W2091726345 created "2016-06-24" @default.
• W2091726345 creator A5003078114 @default.
• W2091726345 creator A5011041566 @default.
• W2091726345 creator A5011474946 @default.
• W2091726345 creator A5012761158 @default.
• W2091726345 creator A5015570891 @default.
• W2091726345 creator A5022589029 @default.
• W2091726345 creator A5039555097 @default.
• W2091726345 creator A5050672651 @default.
• W2091726345 creator A5050712487 @default.
• W2091726345 creator A5054480672 @default.
• W2091726345 creator A5062592597 @default.
• W2091726345 creator A5068598330 @default.
• W2091726345 creator A5075208609 @default.
• W2091726345 date "2007-06-20" @default.
• W2091726345 modified "2023-10-14" @default.
• W2091726345 title "Adolescent Rats Find Repeated Δ9-THC Less Aversive Than Adult Rats but Display Greater Residual Cognitive Deficits and Changes in Hippocampal Protein Expression Following Exposure" @default.
• W2091726345 cites W1531305298 @default.
• W2091726345 cites W1624082697 @default.
• W2091726345 cites W1965117109 @default.
• W2091726345 cites W1966112595 @default.
• W2091726345 cites W1968316735 @default.
• W2091726345 cites W1970497135 @default.
• W2091726345 cites W1979338446 @default.
• W2091726345 cites W1984032966 @default.
• W2091726345 cites W1985579470 @default.
• W2091726345 cites W1985645068 @default.
• W2091726345 cites W1985916296 @default.
• W2091726345 cites W1990261175 @default.
• W2091726345 cites W1991518427 @default.
• W2091726345 cites W1994818402 @default.
• W2091726345 cites W1995327871 @default.
• W2091726345 cites W1999561105 @default.
• W2091726345 cites W2006340284 @default.
• W2091726345 cites W2007495619 @default.
• W2091726345 cites W2008257668 @default.
• W2091726345 cites W2019924561 @default.
• W2091726345 cites W2029181309 @default.
• W2091726345 cites W2030349992 @default.
• W2091726345 cites W2035020078 @default.
• W2091726345 cites W2037047983 @default.
• W2091726345 cites W2038130139 @default.
• W2091726345 cites W2038633869 @default.
• W2091726345 cites W2038813826 @default.
• W2091726345 cites W2039075249 @default.
• W2091726345 cites W2040923467 @default.
• W2091726345 cites W2045785282 @default.
• W2091726345 cites W2056891327 @default.
• W2091726345 cites W2056919557 @default.
• W2091726345 cites W2059356329 @default.
• W2091726345 cites W2060528629 @default.
• W2091726345 cites W2062212900 @default.
• W2091726345 cites W2062723619 @default.
• W2091726345 cites W2064090282 @default.
• W2091726345 cites W2071922977 @default.
• W2091726345 cites W2072441360 @default.
• W2091726345 cites W2076623063 @default.
• W2091726345 cites W2080919590 @default.
• W2091726345 cites W2083010678 @default.
• W2091726345 cites W2084606761 @default.
• W2091726345 cites W2085052787 @default.
• W2091726345 cites W2085515483 @default.
• W2091726345 cites W2088520957 @default.
• W2091726345 cites W2091283126 @default.
• W2091726345 cites W2091339065 @default.
• W2091726345 cites W2096252603 @default.
• W2091726345 cites W2098761670 @default.
• W2091726345 cites W2102773298 @default.
• W2091726345 cites W2107585091 @default.
• W2091726345 cites W2112924959 @default.
• W2091726345 cites W2114192904 @default.
• W2091726345 cites W2115417966 @default.
• W2091726345 cites W2117297654 @default.
• W2091726345 cites W2121082411 @default.
• W2091726345 cites W2123124891 @default.
• W2091726345 cites W2123923673 @default.
• W2091726345 cites W2134263982 @default.
• W2091726345 cites W2135147128 @default.
• W2091726345 cites W2137288204 @default.
• W2091726345 cites W2153898074 @default.
• W2091726345 cites W2164977619 @default.
• W2091726345 cites W2171275714 @default.
• W2091726345 cites W2312531092 @default.
• W2091726345 cites W2331725123 @default.
• W2091726345 cites W4240879629 @default.
• W2091726345 cites W4242322688 @default.
• W2091726345 cites W4256399101 @default.
• W2091726345 cites W4293247451 @default.
• W2091726345 cites W4322703223 @default.
• W2091726345 doi "https://doi.org/10.1038/sj.npp.1301475" @default.
• W2091726345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17581536" @default.
• W2091726345 hasPublicationYear "2007" @default.
• W2091726345 type Work @default.
• W2091726345 sameAs 2091726345 @default.
• W2091726345 citedByCount "270" @default.
• W2091726345 countsByYear W20917263452012 @default.
• W2091726345 countsByYear W20917263452013 @default.

• next