Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091727592> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2091727592 abstract "To elucidate the impacts of member of transcription factor AP-2(α, β or γ) on survivin gene expression in cancer cells and to provide a theoretical base for targeted suppression of survivin gene in tumor cells, the survivin core promoter pLuc- 230 and one of AP-2 member expression vectors (α, β or γ) or control empty vector were cotransfected into Hela cells to detect the impacts of AP-2 on the activity of survivin core promoter. Then, the regulation of survivin expression by AP-2 was detected with reverse transcriptase-polymerase chain reaction (RT-PCR) and Western blot after transfection for 48 hours. It was shown that AP-2(α or γ) could significantly inhibit the activity of survivin core promoter in Hela cells(p<0.05)while AP-2β did not show such difference. In addition, AP-2 also partly inhibited survivin expression at the transcription level and translation levels in cancer cells. Thus, Inhibition of survivin expression in Hela cells by AP-2 may open up a new approach for effective regulation of survivin gene and provide a potential base for survivin-targeted cancer therapy. Keywords- Survivin; transcription factor; AP-2; cancer cell" @default.
- W2091727592 created "2016-06-24" @default.
- W2091727592 creator A5027674029 @default.
- W2091727592 creator A5036607488 @default.
- W2091727592 creator A5051439492 @default.
- W2091727592 creator A5054914766 @default.
- W2091727592 creator A5075418869 @default.
- W2091727592 date "2009-06-01" @default.
- W2091727592 modified "2023-10-16" @default.
- W2091727592 title "Transcription Factor AP-2 Inhibits Survivin Expression" @default.
- W2091727592 cites W138029989 @default.
- W2091727592 cites W1594228172 @default.
- W2091727592 cites W1595083214 @default.
- W2091727592 cites W1662899239 @default.
- W2091727592 cites W1677751641 @default.
- W2091727592 cites W1965336678 @default.
- W2091727592 cites W1971615566 @default.
- W2091727592 cites W1997791083 @default.
- W2091727592 cites W2040396979 @default.
- W2091727592 cites W2082480920 @default.
- W2091727592 doi "https://doi.org/10.1109/icbbe.2009.5163696" @default.
- W2091727592 hasPublicationYear "2009" @default.
- W2091727592 type Work @default.
- W2091727592 sameAs 2091727592 @default.
- W2091727592 citedByCount "0" @default.
- W2091727592 crossrefType "proceedings-article" @default.
- W2091727592 hasAuthorship W2091727592A5027674029 @default.
- W2091727592 hasAuthorship W2091727592A5036607488 @default.
- W2091727592 hasAuthorship W2091727592A5051439492 @default.
- W2091727592 hasAuthorship W2091727592A5054914766 @default.
- W2091727592 hasAuthorship W2091727592A5075418869 @default.
- W2091727592 hasConcept C101762097 @default.
- W2091727592 hasConcept C104317684 @default.
- W2091727592 hasConcept C121608353 @default.
- W2091727592 hasConcept C138885662 @default.
- W2091727592 hasConcept C1491633281 @default.
- W2091727592 hasConcept C150194340 @default.
- W2091727592 hasConcept C153911025 @default.
- W2091727592 hasConcept C179926584 @default.
- W2091727592 hasConcept C185592680 @default.
- W2091727592 hasConcept C2775975398 @default.
- W2091727592 hasConcept C2777366897 @default.
- W2091727592 hasConcept C33161422 @default.
- W2091727592 hasConcept C40767141 @default.
- W2091727592 hasConcept C41895202 @default.
- W2091727592 hasConcept C502942594 @default.
- W2091727592 hasConcept C54009773 @default.
- W2091727592 hasConcept C54355233 @default.
- W2091727592 hasConcept C55493867 @default.
- W2091727592 hasConcept C86339819 @default.
- W2091727592 hasConcept C86803240 @default.
- W2091727592 hasConcept C96232424 @default.
- W2091727592 hasConceptScore W2091727592C101762097 @default.
- W2091727592 hasConceptScore W2091727592C104317684 @default.
- W2091727592 hasConceptScore W2091727592C121608353 @default.
- W2091727592 hasConceptScore W2091727592C138885662 @default.
- W2091727592 hasConceptScore W2091727592C1491633281 @default.
- W2091727592 hasConceptScore W2091727592C150194340 @default.
- W2091727592 hasConceptScore W2091727592C153911025 @default.
- W2091727592 hasConceptScore W2091727592C179926584 @default.
- W2091727592 hasConceptScore W2091727592C185592680 @default.
- W2091727592 hasConceptScore W2091727592C2775975398 @default.
- W2091727592 hasConceptScore W2091727592C2777366897 @default.
- W2091727592 hasConceptScore W2091727592C33161422 @default.
- W2091727592 hasConceptScore W2091727592C40767141 @default.
- W2091727592 hasConceptScore W2091727592C41895202 @default.
- W2091727592 hasConceptScore W2091727592C502942594 @default.
- W2091727592 hasConceptScore W2091727592C54009773 @default.
- W2091727592 hasConceptScore W2091727592C54355233 @default.
- W2091727592 hasConceptScore W2091727592C55493867 @default.
- W2091727592 hasConceptScore W2091727592C86339819 @default.
- W2091727592 hasConceptScore W2091727592C86803240 @default.
- W2091727592 hasConceptScore W2091727592C96232424 @default.
- W2091727592 hasLocation W20917275921 @default.
- W2091727592 hasOpenAccess W2091727592 @default.
- W2091727592 hasPrimaryLocation W20917275921 @default.
- W2091727592 hasRelatedWork W1829661982 @default.
- W2091727592 hasRelatedWork W1966963428 @default.
- W2091727592 hasRelatedWork W1997816904 @default.
- W2091727592 hasRelatedWork W1999978450 @default.
- W2091727592 hasRelatedWork W2029738976 @default.
- W2091727592 hasRelatedWork W2034392527 @default.
- W2091727592 hasRelatedWork W2047634464 @default.
- W2091727592 hasRelatedWork W2071955359 @default.
- W2091727592 hasRelatedWork W2080791039 @default.
- W2091727592 hasRelatedWork W2099785190 @default.
- W2091727592 hasRelatedWork W2115608911 @default.
- W2091727592 hasRelatedWork W2168724272 @default.
- W2091727592 hasRelatedWork W2349018520 @default.
- W2091727592 hasRelatedWork W2368337945 @default.
- W2091727592 hasRelatedWork W2372749489 @default.
- W2091727592 hasRelatedWork W2380946870 @default.
- W2091727592 hasRelatedWork W2391713469 @default.
- W2091727592 hasRelatedWork W2891835310 @default.
- W2091727592 hasRelatedWork W2980324270 @default.
- W2091727592 hasRelatedWork W3030965716 @default.
- W2091727592 isParatext "false" @default.
- W2091727592 isRetracted "false" @default.
- W2091727592 magId "2091727592" @default.
- W2091727592 workType "article" @default.