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- W2091743008 abstract "Introduction Normolipidemic dislipoproteinemias include various disorders of different lipoproteins, of their subfractions or some apolipoproteins, of primary or secondary origin, which are widespread among general population and, like hyperlipoproteinemias, they are associated with the risk for premature atherosclerosis. Decreased level of HDL cholesterol It is a primary, familial hypoalphalipoproteinemia, which is commonly associated with obesity, diet rich in carbohydrates, decreased physical activity and excessive use of coffee and some drugs. Hyperapobetalipoproteinemia It is characterized by increase of apo B-100 in LDL particles, most probably as a consequence of increased hepatic synthesis. Apolipoprotein E isoforms ApoE4 isoform is associated with elevated LDL-cholesterol concentration due to rapid IDL to LDL conversion. Electrophoretic disorders The most important is the latent type IV (pre-beta) or IVb (pre-beta1) with decreased VLDL clearance. Prolonged postprandial lipemia It is common in obesity, NIDDM and coronary heart disease, as an independent risk factor for premature atherosclerosis. Increased oxidative modification of the LDL and HDL particles Oxidatively modified LDL may have a key role in the pathogenesis of atherosclerosis and oxidative modification of HDL reduces its transport capacity and its inhibition of LDL oxidation. Increased level of Lp(a) Lp(a) is an independent risk factor for premature atherosclerosis, primarily in young and middle-aged men, in persons with elevated global cardiovascular risk factor profile, decreased HDL-cholesterol, and hypertension. The risk is smaller in persons taking hypocholesterolemic drugs. Also, it is elevated in NIDDM, hypothyroidism and kidney disease." @default.
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- W2091743008 date "2004-01-01" @default.
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- W2091743008 title "New aspects of normolipidemic dyslipoproteinemias" @default.
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- W2091743008 doi "https://doi.org/10.2298/mpns0412605d" @default.
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