Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091746421> ?p ?o ?g. }
- W2091746421 endingPage "12352" @default.
- W2091746421 startingPage "12346" @default.
- W2091746421 abstract "The isolation, quantitation, and characterization of drug metabolites in biological fluids remain challenging. Rapid access to oxidized drugs could facilitate metabolite identification and enable early pharmacology and toxicity studies. Herein, we compared biotransformations to classical and new chemical C–H oxidation methods using oxcarbazepine, naproxen, and an early compound hit (phthalazine 1). These studies illustrated the low preparative efficacy of biotransformations and the inability of chemical methods to oxidize complex pharmaceuticals. We also disclose an aerobic catalytic protocole (CuI/air) to oxidize tertiary amines and benzylic CH’s in drugs. The reaction tolerates a broad range of functionalities and displays a high level of chemoselectivity, which is not generally explained by the strength of the C–H bonds but by the individual structural chemotype. This study represents a first step toward establishing a chemical toolkit (chemotransformations) that can selectively oxidize C–H bonds in complex pharmaceuticals and rapidly deliver drug metabolites." @default.
- W2091746421 created "2016-06-24" @default.
- W2091746421 creator A5021452033 @default.
- W2091746421 creator A5039778021 @default.
- W2091746421 creator A5068641351 @default.
- W2091746421 creator A5072276505 @default.
- W2091746421 date "2013-08-12" @default.
- W2091746421 modified "2023-09-27" @default.
- W2091746421 title "Complementation of Biotransformations with Chemical C–H Oxidation: Copper-Catalyzed Oxidation of Tertiary Amines in Complex Pharmaceuticals" @default.
- W2091746421 cites W11593016 @default.
- W2091746421 cites W1528712515 @default.
- W2091746421 cites W1967700647 @default.
- W2091746421 cites W1971223189 @default.
- W2091746421 cites W1972672599 @default.
- W2091746421 cites W1973997890 @default.
- W2091746421 cites W1974001124 @default.
- W2091746421 cites W1976425696 @default.
- W2091746421 cites W1982544890 @default.
- W2091746421 cites W1985846963 @default.
- W2091746421 cites W1992136391 @default.
- W2091746421 cites W1994904386 @default.
- W2091746421 cites W1996935441 @default.
- W2091746421 cites W1997852018 @default.
- W2091746421 cites W2004603206 @default.
- W2091746421 cites W2008616263 @default.
- W2091746421 cites W2015216007 @default.
- W2091746421 cites W2015674702 @default.
- W2091746421 cites W2019406135 @default.
- W2091746421 cites W2020103132 @default.
- W2091746421 cites W2028639476 @default.
- W2091746421 cites W2037107024 @default.
- W2091746421 cites W2043570756 @default.
- W2091746421 cites W2049355783 @default.
- W2091746421 cites W2057682369 @default.
- W2091746421 cites W2060197675 @default.
- W2091746421 cites W2060615372 @default.
- W2091746421 cites W2061774444 @default.
- W2091746421 cites W2062651906 @default.
- W2091746421 cites W2076356878 @default.
- W2091746421 cites W2079515082 @default.
- W2091746421 cites W2081421786 @default.
- W2091746421 cites W2087606452 @default.
- W2091746421 cites W2087982186 @default.
- W2091746421 cites W2090102361 @default.
- W2091746421 cites W2090560403 @default.
- W2091746421 cites W2093977714 @default.
- W2091746421 cites W2117819606 @default.
- W2091746421 cites W2120727861 @default.
- W2091746421 cites W2122010784 @default.
- W2091746421 cites W2123771203 @default.
- W2091746421 cites W2124486126 @default.
- W2091746421 cites W2124524221 @default.
- W2091746421 cites W2128969383 @default.
- W2091746421 cites W2132819328 @default.
- W2091746421 cites W2135541782 @default.
- W2091746421 cites W2151787606 @default.
- W2091746421 cites W2153580906 @default.
- W2091746421 cites W2161121683 @default.
- W2091746421 cites W2162005336 @default.
- W2091746421 cites W2164631251 @default.
- W2091746421 cites W2315783058 @default.
- W2091746421 cites W2326386292 @default.
- W2091746421 cites W2333047983 @default.
- W2091746421 cites W2415708495 @default.
- W2091746421 cites W2949396319 @default.
- W2091746421 cites W2952805325 @default.
- W2091746421 cites W4249012482 @default.
- W2091746421 doi "https://doi.org/10.1021/ja405471h" @default.
- W2091746421 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23875728" @default.
- W2091746421 hasPublicationYear "2013" @default.
- W2091746421 type Work @default.
- W2091746421 sameAs 2091746421 @default.
- W2091746421 citedByCount "56" @default.
- W2091746421 countsByYear W20917464212014 @default.
- W2091746421 countsByYear W20917464212015 @default.
- W2091746421 countsByYear W20917464212016 @default.
- W2091746421 countsByYear W20917464212017 @default.
- W2091746421 countsByYear W20917464212018 @default.
- W2091746421 countsByYear W20917464212019 @default.
- W2091746421 countsByYear W20917464212020 @default.
- W2091746421 countsByYear W20917464212021 @default.
- W2091746421 countsByYear W20917464212022 @default.
- W2091746421 countsByYear W20917464212023 @default.
- W2091746421 crossrefType "journal-article" @default.
- W2091746421 hasAuthorship W2091746421A5021452033 @default.
- W2091746421 hasAuthorship W2091746421A5039778021 @default.
- W2091746421 hasAuthorship W2091746421A5068641351 @default.
- W2091746421 hasAuthorship W2091746421A5072276505 @default.
- W2091746421 hasConcept C161790260 @default.
- W2091746421 hasConcept C178790620 @default.
- W2091746421 hasConcept C181199279 @default.
- W2091746421 hasConcept C185592680 @default.
- W2091746421 hasConcept C190667039 @default.
- W2091746421 hasConcept C21951064 @default.
- W2091746421 hasConcept C2777477808 @default.
- W2091746421 hasConcept C27881333 @default.
- W2091746421 hasConcept C55493867 @default.
- W2091746421 hasConceptScore W2091746421C161790260 @default.