Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091749767> ?p ?o ?g. }
- W2091749767 endingPage "23056" @default.
- W2091749767 startingPage "23047" @default.
- W2091749767 abstract "Cell division cycle 48 (CDC48), a ubiquitin-dependent molecular chaperone, is thought to mediate a variety of degradative and regulatory processes and maintain cellular homoeostasis. To investigate the protective function of CDC48 against accumulated ubiquitinated proteins during neurodevelopment, we developed an in vivo bioassay technique that detects expression and accumulation of fluorescent proteins with a polyubiquitination signal at the N terminus. When we introduced CDC48 antisense morpholino oligonucleotides into zebrafish embryos, the morphant embryos were lethal and showed defects in neuronal outgrowth and neurodegeneration, and polyubiquitinated fluorescent proteins accumulated in the inner plexiform and ganglion cell layers, as well as the diencephalon and mesencephalon, indicating that the degradation of polyubiquitinated proteins by the ubiquitin-proteasome system was blocked. These abnormal phenotypes in the morphant were rescued by CDC48 or human valosin-containing protein overexpression. Therefore, the protective function of CDC48 is essential for neurodevelopment." @default.
- W2091749767 created "2016-06-24" @default.
- W2091749767 creator A5016036768 @default.
- W2091749767 creator A5037143835 @default.
- W2091749767 creator A5079556204 @default.
- W2091749767 date "2012-06-01" @default.
- W2091749767 modified "2023-10-16" @default.
- W2091749767 title "Protective Role of Cell Division Cycle 48 (CDC48) Protein against Neurodegeneration via Ubiquitin-Proteasome System Dysfunction during Zebrafish Development" @default.
- W2091749767 cites W1527254461 @default.
- W2091749767 cites W1572511935 @default.
- W2091749767 cites W1649950618 @default.
- W2091749767 cites W1969342645 @default.
- W2091749767 cites W1978167568 @default.
- W2091749767 cites W1981434287 @default.
- W2091749767 cites W1986111043 @default.
- W2091749767 cites W1989634299 @default.
- W2091749767 cites W1993584606 @default.
- W2091749767 cites W1996109826 @default.
- W2091749767 cites W1997559284 @default.
- W2091749767 cites W1998756807 @default.
- W2091749767 cites W1999001130 @default.
- W2091749767 cites W1999975922 @default.
- W2091749767 cites W2000874341 @default.
- W2091749767 cites W2011269026 @default.
- W2091749767 cites W2013987722 @default.
- W2091749767 cites W2014609759 @default.
- W2091749767 cites W2017764563 @default.
- W2091749767 cites W2033088972 @default.
- W2091749767 cites W2040833814 @default.
- W2091749767 cites W2043345690 @default.
- W2091749767 cites W2046615147 @default.
- W2091749767 cites W2051152369 @default.
- W2091749767 cites W2056607803 @default.
- W2091749767 cites W2063509106 @default.
- W2091749767 cites W2064136366 @default.
- W2091749767 cites W2065102063 @default.
- W2091749767 cites W2070226794 @default.
- W2091749767 cites W2073540852 @default.
- W2091749767 cites W2081631520 @default.
- W2091749767 cites W2084858513 @default.
- W2091749767 cites W2085100616 @default.
- W2091749767 cites W2086457894 @default.
- W2091749767 cites W2087436338 @default.
- W2091749767 cites W2090008684 @default.
- W2091749767 cites W2100599614 @default.
- W2091749767 cites W2103523795 @default.
- W2091749767 cites W2111092938 @default.
- W2091749767 cites W2118480670 @default.
- W2091749767 cites W2122974699 @default.
- W2091749767 cites W2125349610 @default.
- W2091749767 cites W2131951074 @default.
- W2091749767 cites W2138247439 @default.
- W2091749767 cites W2139772062 @default.
- W2091749767 cites W2146181664 @default.
- W2091749767 cites W2146969978 @default.
- W2091749767 cites W2149799872 @default.
- W2091749767 cites W2151540861 @default.
- W2091749767 cites W2154096590 @default.
- W2091749767 cites W2154419144 @default.
- W2091749767 cites W2155946179 @default.
- W2091749767 cites W2155971660 @default.
- W2091749767 cites W2171862076 @default.
- W2091749767 doi "https://doi.org/10.1074/jbc.m111.332882" @default.
- W2091749767 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3391108" @default.
- W2091749767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22549779" @default.
- W2091749767 hasPublicationYear "2012" @default.
- W2091749767 type Work @default.
- W2091749767 sameAs 2091749767 @default.
- W2091749767 citedByCount "22" @default.
- W2091749767 countsByYear W20917497672014 @default.
- W2091749767 countsByYear W20917497672015 @default.
- W2091749767 countsByYear W20917497672016 @default.
- W2091749767 countsByYear W20917497672017 @default.
- W2091749767 countsByYear W20917497672018 @default.
- W2091749767 countsByYear W20917497672019 @default.
- W2091749767 countsByYear W20917497672020 @default.
- W2091749767 countsByYear W20917497672021 @default.
- W2091749767 countsByYear W20917497672022 @default.
- W2091749767 countsByYear W20917497672023 @default.
- W2091749767 crossrefType "journal-article" @default.
- W2091749767 hasAuthorship W2091749767A5016036768 @default.
- W2091749767 hasAuthorship W2091749767A5037143835 @default.
- W2091749767 hasAuthorship W2091749767A5079556204 @default.
- W2091749767 hasBestOaLocation W20917497671 @default.
- W2091749767 hasConcept C104317684 @default.
- W2091749767 hasConcept C136571751 @default.
- W2091749767 hasConcept C142724271 @default.
- W2091749767 hasConcept C1491633281 @default.
- W2091749767 hasConcept C25602115 @default.
- W2091749767 hasConcept C27740335 @default.
- W2091749767 hasConcept C2776878037 @default.
- W2091749767 hasConcept C2776925932 @default.
- W2091749767 hasConcept C2779134260 @default.
- W2091749767 hasConcept C29537977 @default.
- W2091749767 hasConcept C55493867 @default.
- W2091749767 hasConcept C71924100 @default.
- W2091749767 hasConcept C86803240 @default.
- W2091749767 hasConcept C95444343 @default.