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- W2091750558 abstract "In the procedure described for evaluating diuretic activity in rats preliminary forced hydration of the animals may be omitted before the administration of the test dose which in itself does produce some hydration. The rats were starved overnight and the dose given orally or intraperitoneally in 0.5 ml. of water for each 100 Gm. weight. Three animals, each weighing 150–250 Gm., were dosed and grouped together in a metabolism cage resting on a polyethylene funnel for urine collection at four-hour and twenty-hour intervals. Values for urine volume, pH, sodium, and chloride were recorded. Ranges for the usual kesponses following water administration alone have been defined statistically for control values and amounts above these indicated typical diuretic responses. These actions were divided into two categories: natriuretic activity which increased sodium excretion in a large volume with high pH; and saluretic activity which may be further differentiated into: ( a ) pyrimidine, purine, and chlorothiazide types—immediate volume increase with saluresis; ( b ) mercurials—variable increased volume and sodium but decreased chloride excretion in twenty-hour period; and ( c ) miscellaneous types—saluretic activity in limited dose ranges such as with some triazines. Dose-response curves were obtained with known diuretics, and combinations were studied." @default.
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- W2091750558 date "1959-06-01" @default.
- W2091750558 modified "2023-10-04" @default.
- W2091750558 title "Diuretic Activity of Various Compounds as Determined by Urinary Excretion Studies in Rats**Wellcome Research Laboratories, Tuckahoe, N. Y." @default.
- W2091750558 cites W2001920072 @default.
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- W2091750558 doi "https://doi.org/10.1002/jps.3030480612" @default.
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