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- W2091753184 abstract "The addition of omeprazole to classical triple therapy for eradication of H. pylori may enhance compliance through reducing ulcer symptoms and side-effects. The aim of this study was to investigate the effects of a 5-day administration of omeprazole on metronidazole pharmacokinetics.Fourteen healthy male volunteers were selected. The study had an open, randomized, two-period crossover design with a 21-day washout period between the phases. Plasma concentrations of metronidazole and its hydroxy-metabolite were measured by reversed-phase HPLC with ultraviolet detection.Administration of omeprazole did not affect the pharmacokinetic parameters of orally administered metronidazole.Our results indicate that short-term treatment with omeprazole in healthy volunteers does not alter the extent or the rate of metronidazole absorption, and does not affect metronidazole clearance." @default.
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- W2091753184 date "1998-04-01" @default.
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- W2091753184 title "Acid suppression by omeprazole does not affect orally administered metronidazole bioavailability and metabolism in healthy male volunteers" @default.
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- W2091753184 doi "https://doi.org/10.1046/j.1365-2036.1998.00298.x" @default.
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