FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091756209> ?p ?o ?g. }

• W2091756209 endingPage "1449" @default.
• W2091756209 startingPage "1443" @default.
• W2091756209 abstract "Desmoid tumours are locally invasive soft tissue tumours in which beta-catenin mediated TCF-dependent transcription is activated. The role of soluble factors secreted by the myofibroblastic desmoid tumour, which could stimulate tumour invasiveness, was investigated. Using collagen gel invasion assays, the presence of factors stimulating invasion in desmoid conditioned media (CM) could be established. Since matrix metalloproteinases (MMPs) have been implicated in the process of tumoral invasion, the expression levels of the MMP family members were evaluated. Quantitative reverse transcription-PCR was used to determine the expression levels of MMP1, MMP2, MMP3, MMP7, MMP11, MMP12, MMP13, MMP14 and the inhibitors TIMP1, TIMP2 and TIMP3. Besides overexpression of MMP7, a known TCF-dependent target gene, a striking upregulation of the expression levels of MMP1, MMP3, MMP11, MMP12 and MMP13 in desmoid tumours, compared to unaffected fibroblasts from the same patients, was found. Treating the CM of desmoids with a synthetic and a physiologic MMP inhibitor reduced the invasion-stimulating capacity of the desmoid CM by approximately 50%. These results suggest the involvement of soluble factors, released by the desmoid cells, in stimulating invasion and implicate the MMPs as facilitators of invasion." @default.
• W2091756209 created "2016-06-24" @default.
• W2091756209 creator A5002871057 @default.
• W2091756209 creator A5006704966 @default.
• W2091756209 creator A5008683883 @default.
• W2091756209 creator A5012494150 @default.
• W2091756209 creator A5016004603 @default.
• W2091756209 creator A5019359552 @default.
• W2091756209 creator A5027182289 @default.
• W2091756209 creator A5034687681 @default.
• W2091756209 creator A5043041637 @default.
• W2091756209 creator A5051097333 @default.
• W2091756209 creator A5052083152 @default.
• W2091756209 creator A5086102127 @default.
• W2091756209 date "2004-03-23" @default.
• W2091756209 modified "2023-10-10" @default.
• W2091756209 title "Invasion and MMP expression profile in desmoid tumours" @default.
• W2091756209 cites W148052990 @default.
• W2091756209 cites W1595383321 @default.
• W2091756209 cites W1631165342 @default.
• W2091756209 cites W1982014175 @default.
• W2091756209 cites W1982804269 @default.
• W2091756209 cites W1983609115 @default.
• W2091756209 cites W1992776653 @default.
• W2091756209 cites W2005088732 @default.
• W2091756209 cites W2012130219 @default.
• W2091756209 cites W2020505509 @default.
• W2091756209 cites W2069561137 @default.
• W2091756209 cites W2070102209 @default.
• W2091756209 cites W2086347831 @default.
• W2091756209 cites W2091983867 @default.
• W2091756209 cites W2093074688 @default.
• W2091756209 cites W2107016942 @default.
• W2091756209 cites W2109689528 @default.
• W2091756209 cites W2123424871 @default.
• W2091756209 cites W2158400177 @default.
• W2091756209 cites W2165476613 @default.
• W2091756209 cites W2168489630 @default.
• W2091756209 cites W2225181319 @default.
• W2091756209 cites W2332208732 @default.
• W2091756209 cites W2444390998 @default.
• W2091756209 cites W4115687 @default.
• W2091756209 cites W4242886517 @default.
• W2091756209 doi "https://doi.org/10.1038/sj.bjc.6601661" @default.
• W2091756209 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2409678" @default.
• W2091756209 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15054469" @default.
• W2091756209 hasPublicationYear "2004" @default.
• W2091756209 type Work @default.
• W2091756209 sameAs 2091756209 @default.
• W2091756209 citedByCount "44" @default.
• W2091756209 countsByYear W20917562092012 @default.
• W2091756209 countsByYear W20917562092013 @default.
• W2091756209 countsByYear W20917562092014 @default.
• W2091756209 countsByYear W20917562092016 @default.
• W2091756209 countsByYear W20917562092019 @default.
• W2091756209 countsByYear W20917562092020 @default.
• W2091756209 countsByYear W20917562092022 @default.
• W2091756209 countsByYear W20917562092023 @default.
• W2091756209 crossrefType "journal-article" @default.
• W2091756209 hasAuthorship W2091756209A5002871057 @default.
• W2091756209 hasAuthorship W2091756209A5006704966 @default.
• W2091756209 hasAuthorship W2091756209A5008683883 @default.
• W2091756209 hasAuthorship W2091756209A5012494150 @default.
• W2091756209 hasAuthorship W2091756209A5016004603 @default.
• W2091756209 hasAuthorship W2091756209A5019359552 @default.
• W2091756209 hasAuthorship W2091756209A5027182289 @default.
• W2091756209 hasAuthorship W2091756209A5034687681 @default.
• W2091756209 hasAuthorship W2091756209A5043041637 @default.
• W2091756209 hasAuthorship W2091756209A5051097333 @default.
• W2091756209 hasAuthorship W2091756209A5052083152 @default.
• W2091756209 hasAuthorship W2091756209A5086102127 @default.
• W2091756209 hasBestOaLocation W20917562091 @default.
• W2091756209 hasConcept C104317684 @default.
• W2091756209 hasConcept C109523444 @default.
• W2091756209 hasConcept C127561419 @default.
• W2091756209 hasConcept C129527566 @default.
• W2091756209 hasConcept C142724271 @default.
• W2091756209 hasConcept C150194340 @default.
• W2091756209 hasConcept C2779295440 @default.
• W2091756209 hasConcept C2780692422 @default.
• W2091756209 hasConcept C2780699576 @default.
• W2091756209 hasConcept C502942594 @default.
• W2091756209 hasConcept C54355233 @default.
• W2091756209 hasConcept C55728118 @default.
• W2091756209 hasConcept C71924100 @default.
• W2091756209 hasConcept C86339819 @default.
• W2091756209 hasConcept C86803240 @default.
• W2091756209 hasConceptScore W2091756209C104317684 @default.
• W2091756209 hasConceptScore W2091756209C109523444 @default.
• W2091756209 hasConceptScore W2091756209C127561419 @default.
• W2091756209 hasConceptScore W2091756209C129527566 @default.
• W2091756209 hasConceptScore W2091756209C142724271 @default.
• W2091756209 hasConceptScore W2091756209C150194340 @default.
• W2091756209 hasConceptScore W2091756209C2779295440 @default.
• W2091756209 hasConceptScore W2091756209C2780692422 @default.
• W2091756209 hasConceptScore W2091756209C2780699576 @default.
• W2091756209 hasConceptScore W2091756209C502942594 @default.
• W2091756209 hasConceptScore W2091756209C54355233 @default.

• next