Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091764984> ?p ?o ?g. }
- W2091764984 endingPage "9412" @default.
- W2091764984 startingPage "9402" @default.
- W2091764984 abstract "Hormones provide generalized signals that are interpreted in a specific spatial and temporal manner by a developing or reproducing multicellular organism. The ability to respond to hormones is determined by the competence of a cell or a tissue. The betaFtz-F1 orphan nuclear receptor acts as a competence factor for the steroid hormone 20-hydroxyecdysone (20E) in Drosophila melanogaster metamorphosis and mosquito reproduction. The molecular nature of the betaFtz-F1 action remains unclear. We report that the protein-protein interaction between betaFtz-F1 and a p160/SRC coactivator of the ecdysone receptor, FISC, is crucial for the stage-specific expression of the 20E effector genes during mosquito reproduction. This interaction dramatically increases recruitment of FISC to the functional ecdysone receptor in a 20E-dependent manner. The presence of betaFtz-F1 facilitates loading of FISC and the ecdysone receptor on the target promoters, leading to enhanced local histone H4 acetylation and robust activation of the target genes. Thus, our results reveal the molecular basis of competence for the stage-specific 20E response." @default.
- W2091764984 created "2016-06-24" @default.
- W2091764984 creator A5003042472 @default.
- W2091764984 creator A5015114019 @default.
- W2091764984 creator A5037989560 @default.
- W2091764984 creator A5056585486 @default.
- W2091764984 date "2006-12-01" @default.
- W2091764984 modified "2023-10-15" @default.
- W2091764984 title "The Competence Factor βFtz-F1 Potentiates Ecdysone Receptor Activity via Recruiting a p160/SRC Coactivator" @default.
- W2091764984 cites W1501286679 @default.
- W2091764984 cites W1504527734 @default.
- W2091764984 cites W1597247843 @default.
- W2091764984 cites W1613446635 @default.
- W2091764984 cites W1798563091 @default.
- W2091764984 cites W1973270134 @default.
- W2091764984 cites W1974663161 @default.
- W2091764984 cites W1974999008 @default.
- W2091764984 cites W1984852477 @default.
- W2091764984 cites W1989127602 @default.
- W2091764984 cites W1993104241 @default.
- W2091764984 cites W1993521976 @default.
- W2091764984 cites W1995209206 @default.
- W2091764984 cites W1995940055 @default.
- W2091764984 cites W1998861353 @default.
- W2091764984 cites W2000253856 @default.
- W2091764984 cites W2001251162 @default.
- W2091764984 cites W2003491070 @default.
- W2091764984 cites W2008253949 @default.
- W2091764984 cites W2008514601 @default.
- W2091764984 cites W2009348486 @default.
- W2091764984 cites W2015882117 @default.
- W2091764984 cites W2019125169 @default.
- W2091764984 cites W2021534590 @default.
- W2091764984 cites W2050783910 @default.
- W2091764984 cites W2053982423 @default.
- W2091764984 cites W2057140490 @default.
- W2091764984 cites W2057708838 @default.
- W2091764984 cites W2065247725 @default.
- W2091764984 cites W2079059309 @default.
- W2091764984 cites W2085138441 @default.
- W2091764984 cites W2087517344 @default.
- W2091764984 cites W2088319796 @default.
- W2091764984 cites W2096265140 @default.
- W2091764984 cites W2098035462 @default.
- W2091764984 cites W2113613354 @default.
- W2091764984 cites W2118195172 @default.
- W2091764984 cites W2118736381 @default.
- W2091764984 cites W2119875346 @default.
- W2091764984 cites W2126084294 @default.
- W2091764984 cites W2128435777 @default.
- W2091764984 cites W2132386492 @default.
- W2091764984 cites W2134138119 @default.
- W2091764984 cites W2134212585 @default.
- W2091764984 cites W2156075810 @default.
- W2091764984 cites W2170938891 @default.
- W2091764984 cites W4299799362 @default.
- W2091764984 cites W8328665 @default.
- W2091764984 doi "https://doi.org/10.1128/mcb.01318-06" @default.
- W2091764984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1698532" @default.
- W2091764984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17015464" @default.
- W2091764984 hasPublicationYear "2006" @default.
- W2091764984 type Work @default.
- W2091764984 sameAs 2091764984 @default.
- W2091764984 citedByCount "96" @default.
- W2091764984 countsByYear W20917649842012 @default.
- W2091764984 countsByYear W20917649842013 @default.
- W2091764984 countsByYear W20917649842014 @default.
- W2091764984 countsByYear W20917649842015 @default.
- W2091764984 countsByYear W20917649842016 @default.
- W2091764984 countsByYear W20917649842017 @default.
- W2091764984 countsByYear W20917649842018 @default.
- W2091764984 countsByYear W20917649842019 @default.
- W2091764984 countsByYear W20917649842020 @default.
- W2091764984 countsByYear W20917649842021 @default.
- W2091764984 countsByYear W20917649842022 @default.
- W2091764984 countsByYear W20917649842023 @default.
- W2091764984 crossrefType "journal-article" @default.
- W2091764984 hasAuthorship W2091764984A5003042472 @default.
- W2091764984 hasAuthorship W2091764984A5015114019 @default.
- W2091764984 hasAuthorship W2091764984A5037989560 @default.
- W2091764984 hasAuthorship W2091764984A5056585486 @default.
- W2091764984 hasBestOaLocation W20917649841 @default.
- W2091764984 hasConcept C104317684 @default.
- W2091764984 hasConcept C109130350 @default.
- W2091764984 hasConcept C170493617 @default.
- W2091764984 hasConcept C2107291 @default.
- W2091764984 hasConcept C2777180181 @default.
- W2091764984 hasConcept C2780104201 @default.
- W2091764984 hasConcept C51785407 @default.
- W2091764984 hasConcept C54355233 @default.
- W2091764984 hasConcept C63932345 @default.
- W2091764984 hasConcept C86339819 @default.
- W2091764984 hasConcept C86803240 @default.
- W2091764984 hasConcept C95444343 @default.
- W2091764984 hasConceptScore W2091764984C104317684 @default.
- W2091764984 hasConceptScore W2091764984C109130350 @default.
- W2091764984 hasConceptScore W2091764984C170493617 @default.
- W2091764984 hasConceptScore W2091764984C2107291 @default.