FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091767944> ?p ?o ?g. }

• W2091767944 endingPage "52" @default.
• W2091767944 startingPage "49" @default.
• W2091767944 abstract "The glial cytoplasmic inclusion (GCI) is a histological hallmark for multiple system atrophy (MSA). These inclusions are in oligodendrocytes, contain microtubular structures of 20-30 nm diameter, and can be labelled immunohistochemically with antibodies to ubiquitin, alphaB-crystallin, alpha- and beta-tubulin, and the microtubule-associated protein tau. GCIs have been compared with neuronal inclusions in other neurodegenerative disorders including the neurofibrillary tangles (NFTs) found in Alzheimer's disease (AD), which also contain tau protein. In order to determine whether the tau protein of GCIs in MSA is similar to that observed in AD we used a panel of antibodies to phosphorylation-independent (SMI51, TP007, TP70), dephosphorylation-dependent (Tau.1), and phosphorylation-dependent antibodies to tau and neurofilaments (AT8, AT180, AT270, SMI31, SMI34, RT97, BF10, 8D8). Immunohistochemistry was performed on paraffin wax-embedded brain tissue of the cerebellum, brainstem, and frontal lobes (Brodmann areas 4/6) of ten clinically and neuropathologically well-characterised cases of MSA, two cases of AD, and two normal controls. The NFTs of the AD cases were labelled with all the phosphorylation-dependent and phosphorylation-independent antibodies and with Tau.1 only after treatment with alkaline phosphatase. In contrast, GCIs were immunolabelled by the phosphorylation-independent antibodies and Tau.1, but not by the phosphorylation-dependent antibodies. These data demonstrate that the tau in GCIs is different from the abnormally phosphorylated tau found in AD and is similar to normal adult tau. The mechanism causing the abnormal accumulation of tau in GCIs remains to be elucidated." @default.
• W2091767944 created "2016-06-24" @default.
• W2091767944 creator A5012877366 @default.
• W2091767944 creator A5015512770 @default.
• W2091767944 creator A5018253812 @default.
• W2091767944 creator A5042096844 @default.
• W2091767944 creator A5050474500 @default.
• W2091767944 creator A5072010327 @default.
• W2091767944 date "1997-07-01" @default.
• W2091767944 modified "2023-09-27" @default.
• W2091767944 title "Tau protein in the glial cytoplasmic inclusions of multiple system atrophy can be distinguished from abnormal tau in Alzheimer's disease" @default.
• W2091767944 cites W126426573 @default.
• W2091767944 cites W1540680906 @default.
• W2091767944 cites W1557500714 @default.
• W2091767944 cites W1569078050 @default.
• W2091767944 cites W1958842451 @default.
• W2091767944 cites W1979834756 @default.
• W2091767944 cites W1982063599 @default.
• W2091767944 cites W1990379890 @default.
• W2091767944 cites W1992274803 @default.
• W2091767944 cites W1994030229 @default.
• W2091767944 cites W1996776367 @default.
• W2091767944 cites W2005751488 @default.
• W2091767944 cites W2014758938 @default.
• W2091767944 cites W2015563160 @default.
• W2091767944 cites W2020347380 @default.
• W2091767944 cites W2021326232 @default.
• W2091767944 cites W2033039026 @default.
• W2091767944 cites W2034517679 @default.
• W2091767944 cites W2048716049 @default.
• W2091767944 cites W2052086914 @default.
• W2091767944 cites W2057682957 @default.
• W2091767944 cites W2062772621 @default.
• W2091767944 cites W2064494790 @default.
• W2091767944 cites W2073128231 @default.
• W2091767944 cites W2075199998 @default.
• W2091767944 cites W2090048744 @default.
• W2091767944 cites W2103829129 @default.
• W2091767944 cites W2116068118 @default.
• W2091767944 cites W2146729934 @default.
• W2091767944 cites W2167775119 @default.
• W2091767944 cites W2779635762 @default.
• W2091767944 doi "https://doi.org/10.1016/s0304-3940(97)00474-6" @default.
• W2091767944 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9259461" @default.
• W2091767944 hasPublicationYear "1997" @default.
• W2091767944 type Work @default.
• W2091767944 sameAs 2091767944 @default.
• W2091767944 citedByCount "85" @default.
• W2091767944 countsByYear W20917679442012 @default.
• W2091767944 countsByYear W20917679442013 @default.
• W2091767944 countsByYear W20917679442014 @default.
• W2091767944 countsByYear W20917679442015 @default.
• W2091767944 countsByYear W20917679442016 @default.
• W2091767944 countsByYear W20917679442017 @default.
• W2091767944 countsByYear W20917679442018 @default.
• W2091767944 countsByYear W20917679442019 @default.
• W2091767944 countsByYear W20917679442020 @default.
• W2091767944 countsByYear W20917679442021 @default.
• W2091767944 countsByYear W20917679442022 @default.
• W2091767944 countsByYear W20917679442023 @default.
• W2091767944 crossrefType "journal-article" @default.
• W2091767944 hasAuthorship W2091767944A5012877366 @default.
• W2091767944 hasAuthorship W2091767944A5015512770 @default.
• W2091767944 hasAuthorship W2091767944A5018253812 @default.
• W2091767944 hasAuthorship W2091767944A5042096844 @default.
• W2091767944 hasAuthorship W2091767944A5050474500 @default.
• W2091767944 hasAuthorship W2091767944A5072010327 @default.
• W2091767944 hasConcept C11960822 @default.
• W2091767944 hasConcept C142724271 @default.
• W2091767944 hasConcept C157207234 @default.
• W2091767944 hasConcept C178666793 @default.
• W2091767944 hasConcept C181912034 @default.
• W2091767944 hasConcept C190062978 @default.
• W2091767944 hasConcept C204232928 @default.
• W2091767944 hasConcept C2778670691 @default.
• W2091767944 hasConcept C2779134260 @default.
• W2091767944 hasConcept C2779721402 @default.
• W2091767944 hasConcept C2781172350 @default.
• W2091767944 hasConcept C36124564 @default.
• W2091767944 hasConcept C502032728 @default.
• W2091767944 hasConcept C68026918 @default.
• W2091767944 hasConcept C71924100 @default.
• W2091767944 hasConcept C86803240 @default.
• W2091767944 hasConcept C95444343 @default.
• W2091767944 hasConceptScore W2091767944C11960822 @default.
• W2091767944 hasConceptScore W2091767944C142724271 @default.
• W2091767944 hasConceptScore W2091767944C157207234 @default.
• W2091767944 hasConceptScore W2091767944C178666793 @default.
• W2091767944 hasConceptScore W2091767944C181912034 @default.
• W2091767944 hasConceptScore W2091767944C190062978 @default.
• W2091767944 hasConceptScore W2091767944C204232928 @default.
• W2091767944 hasConceptScore W2091767944C2778670691 @default.
• W2091767944 hasConceptScore W2091767944C2779134260 @default.
• W2091767944 hasConceptScore W2091767944C2779721402 @default.
• W2091767944 hasConceptScore W2091767944C2781172350 @default.
• W2091767944 hasConceptScore W2091767944C36124564 @default.
• W2091767944 hasConceptScore W2091767944C502032728 @default.
• W2091767944 hasConceptScore W2091767944C68026918 @default.

• next