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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091773058> ?p ?o ?g. }

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• W2091773058 abstract "Aminopyrimidine 2 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-cyclopropylpyrimidin-2-amine) emerged from a high throughput screen as a novel 5-HT1A agonist. This compound showed moderate potency for 5-HT1A in binding and functional assays, as well as moderate metabolic stability. Implementation of a strategy for improving metabolic stability by lowering the lipophilicity (c Log D) led to identification of methyl ether 31 (4-(1-(2-(1H-indol-3-yl)ethyl)piperidin-3-yl)-N-(2-methoxyethyl)pyrimidin-2-amine) as a substantially improved compound within the series." @default.
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• W2091773058 date "2009-02-01" @default.
• W2091773058 modified "2023-10-11" @default.
• W2091773058 title "Synthesis and pharmacological evaluation of aminopyrimidine series of 5-HT1A partial agonists" @default.
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• W2091773058 doi "https://doi.org/10.1016/j.bmcl.2008.12.087" @default.
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