FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091774654> ?p ?o ?g. }

• W2091774654 endingPage "R613" @default.
• W2091774654 startingPage "R606" @default.
• W2091774654 abstract "Without oxygen, all mammals suffer neuronal injury and excitotoxic cell death mediated by overactivation of the glutamatergic N-methyl-d-aspartate receptor (NMDAR). The western painted turtle can survive anoxia for months, and downregulation of NMDAR activity is thought to be neuroprotective during anoxia. NMDAR activity is related to the activity of another glutamate receptor, the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor (AMPAR). AMPAR blockade is neuroprotective against anoxic insult in mammals, but the role of AMPARs in the turtle's anoxia tolerance has not been investigated. To determine whether AMPAR activity changes during hypoxia or anoxia in the turtle cortex, whole cell AMPAR currents, AMPAR-mediated excitatory postsynaptic potentials (EPSPs), and excitatory postsynaptic currents (EPSCs) were measured. The effect of AMPAR blockade on normoxic and anoxic NMDAR currents was also examined. During 60 min of normoxia, evoked peak AMPAR currents and the frequencies and amplitudes of EPSPs and EPSCs did not change. During anoxic perfusion, evoked AMPAR peak currents decreased 59.2 ± 5.5 and 60.2 ± 3.5% at 20 and 40 min, respectively. EPSP frequency (EPSP ƒ ) and amplitude decreased 28.7 ± 6.4% and 13.2 ± 1.7%, respectively, and EPSC ƒ and amplitude decreased 50.7 ± 5.1% and 51.3 ± 4.7%, respectively. In contrast, hypoxic (Po 2 = 5%) AMPAR peak currents were potentiated 56.6 ± 20.5 and 54.6 ± 15.8% at 20 and 40 min, respectively. All changes were reversed by reoxygenation. AMPAR currents and EPSPs were abolished by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX). In neurons pretreated with CNQX, anoxic NMDAR currents were reversibly depressed by 49.8 ± 7.9%. These data suggest that AMPARs may undergo channel arrest in the anoxic turtle cortex." @default.
• W2091774654 created "2016-06-24" @default.
• W2091774654 creator A5013454860 @default.
• W2091774654 creator A5070427153 @default.
• W2091774654 creator A5071728431 @default.
• W2091774654 date "2008-02-01" @default.
• W2091774654 modified "2023-10-06" @default.
• W2091774654 title "AMPA receptors undergo channel arrest in the anoxic turtle cortex" @default.
• W2091774654 cites W1541549742 @default.
• W2091774654 cites W1905013283 @default.
• W2091774654 cites W1969087398 @default.
• W2091774654 cites W1972291807 @default.
• W2091774654 cites W1984116072 @default.
• W2091774654 cites W1985415750 @default.
• W2091774654 cites W1985937715 @default.
• W2091774654 cites W1992378167 @default.
• W2091774654 cites W1996542032 @default.
• W2091774654 cites W1997568797 @default.
• W2091774654 cites W1998217227 @default.
• W2091774654 cites W2002495858 @default.
• W2091774654 cites W2004634409 @default.
• W2091774654 cites W2015127031 @default.
• W2091774654 cites W2028633690 @default.
• W2091774654 cites W2029960234 @default.
• W2091774654 cites W2035449121 @default.
• W2091774654 cites W2043641626 @default.
• W2091774654 cites W2056033965 @default.
• W2091774654 cites W2056540503 @default.
• W2091774654 cites W2057724184 @default.
• W2091774654 cites W2073752219 @default.
• W2091774654 cites W2078696233 @default.
• W2091774654 cites W2085172751 @default.
• W2091774654 cites W2089582877 @default.
• W2091774654 cites W2091054012 @default.
• W2091774654 cites W2095358033 @default.
• W2091774654 cites W2097293665 @default.
• W2091774654 cites W2099834228 @default.
• W2091774654 cites W2126564952 @default.
• W2091774654 cites W2128104071 @default.
• W2091774654 cites W2130656511 @default.
• W2091774654 cites W2136017921 @default.
• W2091774654 cites W2144291596 @default.
• W2091774654 cites W2156317836 @default.
• W2091774654 cites W2185826572 @default.
• W2091774654 cites W2189622566 @default.
• W2091774654 cites W2264705436 @default.
• W2091774654 cites W2280007395 @default.
• W2091774654 cites W2336529481 @default.
• W2091774654 cites W2401650200 @default.
• W2091774654 cites W2554311618 @default.
• W2091774654 doi "https://doi.org/10.1152/ajpregu.00433.2007" @default.
• W2091774654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18056983" @default.
• W2091774654 hasPublicationYear "2008" @default.
• W2091774654 type Work @default.
• W2091774654 sameAs 2091774654 @default.
• W2091774654 citedByCount "35" @default.
• W2091774654 countsByYear W20917746542012 @default.
• W2091774654 countsByYear W20917746542013 @default.
• W2091774654 countsByYear W20917746542014 @default.
• W2091774654 countsByYear W20917746542015 @default.
• W2091774654 countsByYear W20917746542016 @default.
• W2091774654 countsByYear W20917746542017 @default.
• W2091774654 countsByYear W20917746542018 @default.
• W2091774654 countsByYear W20917746542019 @default.
• W2091774654 countsByYear W20917746542021 @default.
• W2091774654 countsByYear W20917746542022 @default.
• W2091774654 countsByYear W20917746542023 @default.
• W2091774654 crossrefType "journal-article" @default.
• W2091774654 hasAuthorship W2091774654A5013454860 @default.
• W2091774654 hasAuthorship W2091774654A5070427153 @default.
• W2091774654 hasAuthorship W2091774654A5071728431 @default.
• W2091774654 hasConcept C112592302 @default.
• W2091774654 hasConcept C160268369 @default.
• W2091774654 hasConcept C169760540 @default.
• W2091774654 hasConcept C170493617 @default.
• W2091774654 hasConcept C17077164 @default.
• W2091774654 hasConcept C185592680 @default.
• W2091774654 hasConcept C197341189 @default.
• W2091774654 hasConcept C25498285 @default.
• W2091774654 hasConcept C2780648746 @default.
• W2091774654 hasConcept C55493867 @default.
• W2091774654 hasConcept C61174792 @default.
• W2091774654 hasConcept C67018056 @default.
• W2091774654 hasConcept C86803240 @default.
• W2091774654 hasConceptScore W2091774654C112592302 @default.
• W2091774654 hasConceptScore W2091774654C160268369 @default.
• W2091774654 hasConceptScore W2091774654C169760540 @default.
• W2091774654 hasConceptScore W2091774654C170493617 @default.
• W2091774654 hasConceptScore W2091774654C17077164 @default.
• W2091774654 hasConceptScore W2091774654C185592680 @default.
• W2091774654 hasConceptScore W2091774654C197341189 @default.
• W2091774654 hasConceptScore W2091774654C25498285 @default.
• W2091774654 hasConceptScore W2091774654C2780648746 @default.
• W2091774654 hasConceptScore W2091774654C55493867 @default.
• W2091774654 hasConceptScore W2091774654C61174792 @default.
• W2091774654 hasConceptScore W2091774654C67018056 @default.
• W2091774654 hasConceptScore W2091774654C86803240 @default.
• W2091774654 hasIssue "2" @default.

• next