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- W2091775887 endingPage "710" @default.
- W2091775887 startingPage "687" @default.
- W2091775887 abstract "Patients with type-2 diabetes mellitus (T2DM) are considered to be at particularly high risk for cardiovascular disease. Over the last decade, the members of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors have emerged as valuable pharmacological targets whose activation can normalize metabolic dysfunctions and reduce some cardiovascular risk factors associated with T2DM. PPARα agonists, such as the fibrates, can correct dyslipidemia. PPARγ agonists, such as the thiazolidinediones, act as insulin sensitizers and improve insulin resistance in patients with T2DM. Because of restricted potency and certain side-effects of PPAR agonists, as well as the increasingly epidemic incidence of T2DM, there is a real need for the development of selective PPAR agonists with improved clinical efficacy. This chapter focuses on the PPAR agonists currently used in the clinic, as well as on the discovery and development of the next generation of PPAR agonists." @default.
- W2091775887 created "2016-06-24" @default.
- W2091775887 creator A5001127450 @default.
- W2091775887 creator A5002051079 @default.
- W2091775887 date "2007-12-01" @default.
- W2091775887 modified "2023-10-11" @default.
- W2091775887 title "PPAR agonists: multimodal drugs for the treatment of type-2 diabetes" @default.
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