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- W2091777254 abstract "Abstract Erythrocyte 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase activity was assayed to screen possible variants of this enzyme in 110 patients with clinical gout. The enzyme obtained from one of these patients proved to have the following characteristics: (a) Its activity was about twice higher than the mean value. (b) Its activity was sigmoidally elevated by inorganic phosphate ( P i ) over a wide range of P i concentrations from 1 to 32 m m . (c) Its K m values to ATP and ribose 5-phosphate were identical with the control values. (d) The degree to which it was inhibited by AMP, ADP, and 2,3-DPG did not differ from the finding obtained from the control. (e) It was very unstable at 60°C. (f) Isoelectric focusing revealed that it had an elution profile with two peaks (peak I at pH 4.3 and peak II at pH 5.01, being less stable to heat at peak I than at peak II. These findings suggested that erythrocyte PRPP synthetase obtained from the patient might be a variant resulting from the alteration of its molecular form." @default.
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- W2091777254 date "1981-12-01" @default.
- W2091777254 modified "2023-10-02" @default.
- W2091777254 title "Altered isoelectric property of a superactive 5-phosphoribosyl-1-pyrophosphate (PRPP) synthetase in a patient with clinical gout" @default.
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- W2091777254 doi "https://doi.org/10.1016/0006-2944(81)90014-4" @default.
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