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- W2091781175 abstract "Human blood was exposed to low levels of CdCl/sub 2/ (2 x 10/sup -7/ M) in tissue culture. During a 3-day exposure, Cd was accumulated by the blood cells. Erythrocytes incorporated Cd to a level approx. 5-fold greater than the concentration in the growth medium, while lymphocytes accumulated Cd to a cellular concentration approx. 3000-fold greater than that in the culture medium. In erythrocytes, Cd was bound to several macromolecular species, none of which corresponded to the specific, inducible, Cd-binding protein metallothionein.In contrast, most of the Cd in lymphocytes was found associated with a low-molecular-weight macromolecule characteristic of Cd-thionein. On the basis of these studies showing the accumulation of Cd by lymphocytes and the metabolic response of lymphocytes indicated by the sequestering of Cd in metallothionein, it is possible that Cd exposure may alter normal immunocompetence associated with lymphocytes." @default.
- W2091781175 created "2016-06-24" @default.
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- W2091781175 date "1979-09-01" @default.
- W2091781175 modified "2023-09-23" @default.
- W2091781175 title "Distribution of Cadmium in Human Blood Cultured in Low Levels of CdCI2: Accumulation of Cd in Lymphocytes and Preferential Binding to Metallothionein" @default.
- W2091781175 doi "https://doi.org/10.3181/00379727-161-40569" @default.
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