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• W2091786479 startingPage "1371" @default.
• W2091786479 abstract "Neurokinin B (NKB) is a member of the tachykinin family of neuropeptides that have neuroinflammatory, neuroimmunological, and neuroprotective functions. In a neuroprotective role, tachykinins can help protect cells against the neurotoxic processes observed in Alzheimer's disease. A change in copper homeostasis is a clear feature of Alzheimer's disease, and the dysregulation may be a contributory factor in toxicity. Copper has recently been shown to interact with neurokinin A and neuropeptide γ and can lead to generation of reactive oxygen species and peptide degradation, which suggests that copper may have a place in tachykinin function and potentially misfunction. To explore this, we have utilized a range of spectroscopic techniques to show that NKB, but not substance P, can bind Cu(II) in an unusual [Cu(II)(NKB)2] neutral complex that utilizes two N-terminal amine and two imidazole nitrogen ligands (from each molecule of NKB) and the binding substantially alters the structure of the peptide. Using 1321N1 astrocytoma cells, we show that copper can enter the cells and subsequently open plasma membrane calcium channels but when bound to neurokinin B copper ion uptake is inhibited. This data suggests a novel role for neurokinin B in protecting cells against copper-induced calcium changes and implicates the peptide in synaptic copper homeostasis." @default.
• W2091786479 created "2016-06-24" @default.
• W2091786479 creator A5044286389 @default.
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• W2091786479 creator A5081056588 @default.
• W2091786479 creator A5083779822 @default.
• W2091786479 date "2013-08-07" @default.
• W2091786479 modified "2023-10-18" @default.
• W2091786479 title "The Tachykinin Peptide Neurokinin B Binds Copper Forming an Unusual [Cu^II(NKB)₂] Complex and Inhibits Copper Uptake into 1321N1 Astrocytoma Cells" @default.
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• W2091786479 doi "https://doi.org/10.1021/cn4000988" @default.
• W2091786479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3798990" @default.
• W2091786479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23875773" @default.
• W2091786479 hasPublicationYear "2013" @default.
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