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- W2091788742 abstract "Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage. We propose that the complex nutritional requirements of amastigotes have contributed to the tropism of these parasites for the amino acid-rich phagolysosome of macrophages. Amastigote metabolism in this compartment is robust because many metabolic mutants are capable of either growing normally or persisting long term in susceptible animals. New approaches for measuring amastigote metabolism in vivo are discussed. Leishmania amastigotes primarily proliferate within macrophages in the mammalian host. Genome-based metabolic reconstructions, combined with biochemical, reverse genetic and mRNA or protein profiling studies are providing new insights into the metabolism of this intracellular stage. We propose that the complex nutritional requirements of amastigotes have contributed to the tropism of these parasites for the amino acid-rich phagolysosome of macrophages. Amastigote metabolism in this compartment is robust because many metabolic mutants are capable of either growing normally or persisting long term in susceptible animals. New approaches for measuring amastigote metabolism in vivo are discussed." @default.
- W2091788742 created "2016-06-24" @default.
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- W2091788742 date "2007-08-01" @default.
- W2091788742 modified "2023-10-16" @default.
- W2091788742 title "Living in a phagolysosome; metabolism of Leishmania amastigotes" @default.
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- W2091788742 doi "https://doi.org/10.1016/j.pt.2007.06.009" @default.
- W2091788742 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17606406" @default.
- W2091788742 hasPublicationYear "2007" @default.
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