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- W2091822552 abstract "The basic defect in cystic fibrosis (CF) predisposes to chronic bacterial airway infections, particularly with Pseudomonas aeruginosa. Airway infections with P. aeruginosa in individuals with CF are unique in that they chronically affect a host who is immunocompetent in terms of cellular and humoral responses but is immunocompromised by impaired airway clearance. The initially acquired P. aeruginosa clone typically persists for many years in the patients' airways and thereby diversifies by de novo point mutations and the composition of its accessory genome. Co-colonizations with 2 or more clones are preferentially observed during the first 3 years of colonization. Upper and lower airways are commonly colonized by the same clone suggesting that the sinuses are the reservoir and gateway for the colonization of the lower airways. Early antipseudomonal chemotherapy has an 80% chance to eradicate the P. aeruginosa clone. This regimen introduced in the late 1980s has shifted the median age of the onset of chronic airways colonization with P. aeruginosa from school age to early adulthood at the most successful CF centres. The measures to prevent and to treat the Pseudomonas infections in CF have been considerably improved during the last 20 years. Highly transmissible epidemic strains, however, that emerge within a clonal lineage remain a major, still unresolved health threat for the CF community." @default.
- W2091822552 created "2016-06-24" @default.
- W2091822552 creator A5000198457 @default.
- W2091822552 creator A5000322370 @default.
- W2091822552 creator A5041981028 @default.
- W2091822552 date "2010-12-01" @default.
- W2091822552 modified "2023-10-18" @default.
- W2091822552 title "Clonal epidemiology of Pseudomonas aeruginosa in cystic fibrosis" @default.
- W2091822552 cites W1603754669 @default.
- W2091822552 cites W1603998496 @default.
- W2091822552 cites W1675696738 @default.
- W2091822552 cites W1929202061 @default.
- W2091822552 cites W1967023708 @default.
- W2091822552 cites W1975305392 @default.
- W2091822552 cites W1978046264 @default.
- W2091822552 cites W1979152503 @default.
- W2091822552 cites W1985687704 @default.
- W2091822552 cites W1987865402 @default.
- W2091822552 cites W1993609915 @default.
- W2091822552 cites W2016174414 @default.
- W2091822552 cites W2017197251 @default.
- W2091822552 cites W2026856098 @default.
- W2091822552 cites W2030956160 @default.
- W2091822552 cites W2031398496 @default.
- W2091822552 cites W2042759586 @default.
- W2091822552 cites W2043897270 @default.
- W2091822552 cites W2054318061 @default.
- W2091822552 cites W2058107166 @default.
- W2091822552 cites W2060657293 @default.
- W2091822552 cites W2061914839 @default.
- W2091822552 cites W2065552633 @default.
- W2091822552 cites W2068781163 @default.
- W2091822552 cites W2070094351 @default.
- W2091822552 cites W2070576480 @default.
- W2091822552 cites W2071665252 @default.
- W2091822552 cites W2085224577 @default.
- W2091822552 cites W2085506029 @default.
- W2091822552 cites W2088849723 @default.
- W2091822552 cites W2091990251 @default.
- W2091822552 cites W2093763294 @default.
- W2091822552 cites W2095971260 @default.
- W2091822552 cites W2096684565 @default.
- W2091822552 cites W2096797367 @default.
- W2091822552 cites W2097944090 @default.
- W2091822552 cites W2099209753 @default.
- W2091822552 cites W2099684220 @default.
- W2091822552 cites W2100719455 @default.
- W2091822552 cites W2101667079 @default.
- W2091822552 cites W2102601964 @default.
- W2091822552 cites W2104019857 @default.
- W2091822552 cites W2105587442 @default.
- W2091822552 cites W2106822973 @default.
- W2091822552 cites W2107999177 @default.
- W2091822552 cites W2108862719 @default.
- W2091822552 cites W2109038233 @default.
- W2091822552 cites W2111616620 @default.
- W2091822552 cites W2114120528 @default.
- W2091822552 cites W2115574740 @default.
- W2091822552 cites W2119803749 @default.
- W2091822552 cites W2119986491 @default.
- W2091822552 cites W2122616212 @default.
- W2091822552 cites W2122891454 @default.
- W2091822552 cites W2125615112 @default.
- W2091822552 cites W2133675879 @default.
- W2091822552 cites W2137149853 @default.
- W2091822552 cites W2140059688 @default.
- W2091822552 cites W2141104549 @default.
- W2091822552 cites W2141963202 @default.
- W2091822552 cites W2144601023 @default.
- W2091822552 cites W2145123043 @default.
- W2091822552 cites W2145887242 @default.
- W2091822552 cites W2147494743 @default.
- W2091822552 cites W2149407025 @default.
- W2091822552 cites W2149627743 @default.
- W2091822552 cites W2151703171 @default.
- W2091822552 cites W2152645114 @default.
- W2091822552 cites W2154492506 @default.
- W2091822552 cites W2154494532 @default.
- W2091822552 cites W2155094676 @default.
- W2091822552 cites W2156039720 @default.
- W2091822552 cites W2156196675 @default.
- W2091822552 cites W2157813174 @default.
- W2091822552 cites W2162822457 @default.
- W2091822552 cites W2164327244 @default.
- W2091822552 cites W2165913026 @default.
- W2091822552 cites W2166135736 @default.
- W2091822552 cites W2166730837 @default.
- W2091822552 cites W2166779461 @default.
- W2091822552 cites W2169545551 @default.
- W2091822552 cites W2172025654 @default.
- W2091822552 cites W2994595762 @default.
- W2091822552 doi "https://doi.org/10.1016/j.ijmm.2010.08.004" @default.
- W2091822552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20951087" @default.
- W2091822552 hasPublicationYear "2010" @default.
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