FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091837045> ?p ?o ?g. }

• W2091837045 endingPage "9" @default.
• W2091837045 startingPage "1" @default.
• W2091837045 abstract "The evolution of cats as a solitary species has pressured feline viruses to develop highly efficient transmission strategies, the ability to persist within the host for long periods of time and the aptitude to adapt to natural and vaccine-induced immunological pressures. These characteristics render feline viruses particularly dangerous in catteries, shelters and rescue homes, were cats from different backgrounds live in close proximity. The possibility to induce short-term resistance of newcomer cats to a broad variety of viruses could help prevent the dissemination of viruses both within and outside such facilities. Oligonucleotides (ODN) containing unmethylated cytosine phosphate guanosine (CpG) motifs stimulate innate immune responses in mammals. We have previously shown that ODN 2216, a class A CpG ODN, promotes the expression by feline immune cells of potent antiviral molecules that increase resistance of feline fibroblastic and epithelial cell lines to five common feline viruses. With the aim to test the safety and extent of the biological effects of ODN 2216 in the domestic cat, we performed an initial in vivo experiment in which two cats were injected the molecule once subcutaneously and two additional cats received control treatments. No side effects to administration of ODN 2216 were observed. Moreover, this molecule induced the expression of the myxovirus resistance (Mx) gene, a marker for the instigation of innate antiviral processes, in blood as well as in oral, conjunctival and rectal mucosa cells, indicating systemic biological activity of the molecule with protective potential at viral entry sites. Mx mRNA levels were already elevated in blood 6 h post injection of ODN 2216, reached peak levels within 24 h and returned to basal values by 96–192 h after administration of the molecule. Similar induction patterns were observed in all analyzed mucosal cells. Plasma collected from treated cats at regular intervals until 96–192 h could moreover induce Mx mRNA expression in fcwf-4 cells and increase resistance of these cells to feline calicivirus inoculation. Finally, Mx mRNA levels measured in blood correlated with the degree of viral inhibition that was induced by plasma from the same cat and the same experimental time point. Our results altogether underline the promising potential of ODN 2216 in promoting antiviral defense mechanisms and inducing temporary resistance to viral infections in vivo in the domestic cat." @default.
• W2091837045 created "2016-06-24" @default.
• W2091837045 creator A5030919228 @default.
• W2091837045 creator A5043821652 @default.
• W2091837045 creator A5054243093 @default.
• W2091837045 creator A5073011326 @default.
• W2091837045 creator A5084884183 @default.
• W2091837045 date "2012-11-01" @default.
• W2091837045 modified "2023-09-25" @default.
• W2091837045 title "Induction of a systemic antiviral state in vivo in the domestic cat with a class A CpG oligonucleotide" @default.
• W2091837045 cites W1498867687 @default.
• W2091837045 cites W1577577364 @default.
• W2091837045 cites W1669866646 @default.
• W2091837045 cites W1967744820 @default.
• W2091837045 cites W1969943540 @default.
• W2091837045 cites W1982293159 @default.
• W2091837045 cites W1984618863 @default.
• W2091837045 cites W1984934429 @default.
• W2091837045 cites W2003942638 @default.
• W2091837045 cites W2004084345 @default.
• W2091837045 cites W2005733895 @default.
• W2091837045 cites W2008701262 @default.
• W2091837045 cites W2011764041 @default.
• W2091837045 cites W2014104593 @default.
• W2091837045 cites W2030725681 @default.
• W2091837045 cites W2037764279 @default.
• W2091837045 cites W2037910984 @default.
• W2091837045 cites W2038477905 @default.
• W2091837045 cites W2039623623 @default.
• W2091837045 cites W2043516182 @default.
• W2091837045 cites W2046643465 @default.
• W2091837045 cites W2051717397 @default.
• W2091837045 cites W2052836647 @default.
• W2091837045 cites W2057371900 @default.
• W2091837045 cites W2057837019 @default.
• W2091837045 cites W2066719237 @default.
• W2091837045 cites W2073746638 @default.
• W2091837045 cites W2074779600 @default.
• W2091837045 cites W2076805477 @default.
• W2091837045 cites W2082537000 @default.
• W2091837045 cites W2087144130 @default.
• W2091837045 cites W2089580397 @default.
• W2091837045 cites W2094631594 @default.
• W2091837045 cites W2094666071 @default.
• W2091837045 cites W2099214157 @default.
• W2091837045 cites W2101505589 @default.
• W2091837045 cites W2106454185 @default.
• W2091837045 cites W2109491328 @default.
• W2091837045 cites W2118688691 @default.
• W2091837045 cites W2120663567 @default.
• W2091837045 cites W2122104675 @default.
• W2091837045 cites W2134334638 @default.
• W2091837045 cites W2137188698 @default.
• W2091837045 cites W2140546048 @default.
• W2091837045 cites W2142040352 @default.
• W2091837045 cites W2146549512 @default.
• W2091837045 cites W2152415449 @default.
• W2091837045 cites W2155953213 @default.
• W2091837045 cites W2159746690 @default.
• W2091837045 cites W2236214911 @default.
• W2091837045 cites W4240266822 @default.
• W2091837045 cites W2074572380 @default.
• W2091837045 doi "https://doi.org/10.1016/j.vetimm.2012.07.015" @default.
• W2091837045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7112607" @default.
• W2091837045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22974542" @default.
• W2091837045 hasPublicationYear "2012" @default.
• W2091837045 type Work @default.
• W2091837045 sameAs 2091837045 @default.
• W2091837045 citedByCount "3" @default.
• W2091837045 countsByYear W20918370452013 @default.
• W2091837045 countsByYear W20918370452020 @default.
• W2091837045 countsByYear W20918370452021 @default.
• W2091837045 crossrefType "journal-article" @default.
• W2091837045 hasAuthorship W2091837045A5030919228 @default.
• W2091837045 hasAuthorship W2091837045A5043821652 @default.
• W2091837045 hasAuthorship W2091837045A5054243093 @default.
• W2091837045 hasAuthorship W2091837045A5073011326 @default.
• W2091837045 hasAuthorship W2091837045A5084884183 @default.
• W2091837045 hasBestOaLocation W20918370451 @default.
• W2091837045 hasConcept C104317684 @default.
• W2091837045 hasConcept C126322002 @default.
• W2091837045 hasConcept C136449434 @default.
• W2091837045 hasConcept C140173407 @default.
• W2091837045 hasConcept C150194340 @default.
• W2091837045 hasConcept C159047783 @default.
• W2091837045 hasConcept C190727270 @default.
• W2091837045 hasConcept C203014093 @default.
• W2091837045 hasConcept C207001950 @default.
• W2091837045 hasConcept C22801619 @default.
• W2091837045 hasConcept C25938499 @default.
• W2091837045 hasConcept C2779904517 @default.
• W2091837045 hasConcept C54355233 @default.
• W2091837045 hasConcept C71924100 @default.
• W2091837045 hasConcept C86803240 @default.
• W2091837045 hasConcept C8891405 @default.
• W2091837045 hasConceptScore W2091837045C104317684 @default.
• W2091837045 hasConceptScore W2091837045C126322002 @default.
• W2091837045 hasConceptScore W2091837045C136449434 @default.

• next