Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091837347> ?p ?o ?g. }
- W2091837347 endingPage "637" @default.
- W2091837347 startingPage "626" @default.
- W2091837347 abstract "Liver cancer is the fifth most common cancer in the world with an estimated over half a million new cases diagnosed every year. Due to the difficulty in early diagnosis and lack of treatment options, the prevalence of liver cancer continues to climb with a 5-year survival rate of between 6% and 11%. Coinciding with the rise of liver cancer, the prevalence of obesity has rapidly increased over the past two decades. Evidence from epidemiological studies demonstrates a higher risk of hepatocellular carcinoma (HCC) in obese individuals. Obesity is recognised as a low-grade inflammatory disease, this is of particular relevance as inflammation has been proposed as the seventh hallmark of cancer development with abdominal visceral adiposity considered as an important source of pro-inflammatory stimuli. Emerging evidence points towards the direct role of visceral adipose tissue rather than generalised body fat in carcinogenesis. Cytokines such as IL-6 and TNF-α secreted from visceral adipose tissue have been demonstrated to induce a chronic inflammatory condition predisposing the liver to a protumourigenic milieu. This review focuses on excess visceral adiposity rather than simple obesity; particularly adipokines and their implications for chronic inflammation, lipid accumulation, insulin resistance, Endoplasmic Reticulum (ER) stress and angiogenesis. Evidence of molecular signalling pathways that may give rise to the onset and progression of HCC in this context are depicted. Delineation of the pro-inflammatory role of visceral adiposity in liver cancer and its targeting will provide better rational and therapeutic approaches for HCC prevention and elimination. The concept of a central role for metabolism in cancer is the culmination of an effort that began with one of the 20th century’s leading biochemists and Nobel laureate of 1931, Otto Warburg." @default.
- W2091837347 created "2016-06-24" @default.
- W2091837347 creator A5020814266 @default.
- W2091837347 creator A5031060869 @default.
- W2091837347 date "2013-12-01" @default.
- W2091837347 modified "2023-10-17" @default.
- W2091837347 title "Stop feeding cancer: Pro-inflammatory role of visceral adiposity in liver cancer" @default.
- W2091837347 cites W1545606694 @default.
- W2091837347 cites W1617532721 @default.
- W2091837347 cites W1631449371 @default.
- W2091837347 cites W1764140709 @default.
- W2091837347 cites W1810265271 @default.
- W2091837347 cites W1852831587 @default.
- W2091837347 cites W1964888481 @default.
- W2091837347 cites W1965712234 @default.
- W2091837347 cites W1965917728 @default.
- W2091837347 cites W1966241241 @default.
- W2091837347 cites W1967972402 @default.
- W2091837347 cites W1968020958 @default.
- W2091837347 cites W1969405606 @default.
- W2091837347 cites W1969888505 @default.
- W2091837347 cites W1975437957 @default.
- W2091837347 cites W1976777085 @default.
- W2091837347 cites W1976814494 @default.
- W2091837347 cites W1978583076 @default.
- W2091837347 cites W1981261500 @default.
- W2091837347 cites W1981388207 @default.
- W2091837347 cites W1981503496 @default.
- W2091837347 cites W1983908359 @default.
- W2091837347 cites W1984077928 @default.
- W2091837347 cites W1984865862 @default.
- W2091837347 cites W1985079385 @default.
- W2091837347 cites W1985592156 @default.
- W2091837347 cites W1986533543 @default.
- W2091837347 cites W1988973837 @default.
- W2091837347 cites W1990034749 @default.
- W2091837347 cites W1990330534 @default.
- W2091837347 cites W1990458582 @default.
- W2091837347 cites W1992034322 @default.
- W2091837347 cites W1992439380 @default.
- W2091837347 cites W1992462510 @default.
- W2091837347 cites W1996713062 @default.
- W2091837347 cites W1998588668 @default.
- W2091837347 cites W2001837599 @default.
- W2091837347 cites W2002892549 @default.
- W2091837347 cites W2007078899 @default.
- W2091837347 cites W2007868505 @default.
- W2091837347 cites W2009538093 @default.
- W2091837347 cites W2011810742 @default.
- W2091837347 cites W2012247982 @default.
- W2091837347 cites W2013869557 @default.
- W2091837347 cites W2015815772 @default.
- W2091837347 cites W2016307947 @default.
- W2091837347 cites W2019953132 @default.
- W2091837347 cites W2021970375 @default.
- W2091837347 cites W2021992979 @default.
- W2091837347 cites W2022013872 @default.
- W2091837347 cites W2024468216 @default.
- W2091837347 cites W2027889152 @default.
- W2091837347 cites W2029784795 @default.
- W2091837347 cites W2032749734 @default.
- W2091837347 cites W2032900856 @default.
- W2091837347 cites W2034300770 @default.
- W2091837347 cites W2035134361 @default.
- W2091837347 cites W2035536340 @default.
- W2091837347 cites W2038018821 @default.
- W2091837347 cites W2038616074 @default.
- W2091837347 cites W2039666397 @default.
- W2091837347 cites W2043462108 @default.
- W2091837347 cites W2044227662 @default.
- W2091837347 cites W2044229386 @default.
- W2091837347 cites W2044798581 @default.
- W2091837347 cites W2045151900 @default.
- W2091837347 cites W2049907735 @default.
- W2091837347 cites W2050764448 @default.
- W2091837347 cites W2051051060 @default.
- W2091837347 cites W2051094694 @default.
- W2091837347 cites W2052656103 @default.
- W2091837347 cites W2057123987 @default.
- W2091837347 cites W2058961914 @default.
- W2091837347 cites W2059287377 @default.
- W2091837347 cites W2059739926 @default.
- W2091837347 cites W2061434349 @default.
- W2091837347 cites W2061686058 @default.
- W2091837347 cites W2062289724 @default.
- W2091837347 cites W2062961142 @default.
- W2091837347 cites W2063131576 @default.
- W2091837347 cites W2064776807 @default.
- W2091837347 cites W2065697164 @default.
- W2091837347 cites W2065912402 @default.
- W2091837347 cites W2067197628 @default.
- W2091837347 cites W2069798327 @default.
- W2091837347 cites W2070001214 @default.
- W2091837347 cites W2070396671 @default.
- W2091837347 cites W2071559249 @default.
- W2091837347 cites W2071754972 @default.
- W2091837347 cites W2072839085 @default.
- W2091837347 cites W2075791473 @default.