Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091838071> ?p ?o ?g. }
- W2091838071 endingPage "311" @default.
- W2091838071 startingPage "298" @default.
- W2091838071 abstract "Live attenuated Salmonella enterica strains have been extensively studied as potential vectors for the oral delivery of heterologous antigens. Due to its ability to target immune cells, its specific mechanism for crossing the intestinal barrier, and its swine-restricted tropism, S. enterica subspecies enterica serovar Choleraesuis (S. Choleraesuis) has attracted a great deal of interest for the production of bacterial-based oral carriers specifically adapted to swine. In this study, two mutants of S. Choleraesuis were constructed and their attenuation and intracellular fate analysed with the purpose of engineering new attenuated live strains with improved properties as oral vaccine carriers. Those strains harboured a specific deletion either within the phoP or rpoS genes, which encode virulence-related regulators in S. Typhimurium. In comparison to the wild-type parental S. Choleraesuis, the mutant strains, especially ΔphoP, were extremely low in virulence in the murine model and in the natural host, the pig. Moreover, when compared with a commercial live vaccine strain, SC-54, the two mutants showed a higher level of attenuation in mice and ΔphoP also in pigs. In addition, ΔrpoS and ΔphoP presented a proliferation and survival phenotype within swine intestinal primary fibroblast and macrophage cell cultures, respectively. Collectively, the present results indicate that the ΔrpoS and ΔphoP strains of S. Choleraesuis gather adequate features to be potential candidates for vaccine vectors for the specific delivery of heterologous antigens adapted to pigs." @default.
- W2091838071 created "2016-06-24" @default.
- W2091838071 creator A5005185558 @default.
- W2091838071 creator A5009331769 @default.
- W2091838071 creator A5011475425 @default.
- W2091838071 creator A5027655370 @default.
- W2091838071 creator A5046473514 @default.
- W2091838071 creator A5046833493 @default.
- W2091838071 creator A5049299884 @default.
- W2091838071 date "2008-08-01" @default.
- W2091838071 modified "2023-09-30" @default.
- W2091838071 title "Salmonella enterica serovar Choleraesuis derivatives harbouring deletions in rpoS and phoP regulatory genes are attenuated in pigs, and survive and multiply in porcine intestinal macrophages and fibroblasts, respectively" @default.
- W2091838071 cites W1498762963 @default.
- W2091838071 cites W1517763814 @default.
- W2091838071 cites W1799115436 @default.
- W2091838071 cites W1862154364 @default.
- W2091838071 cites W1970078225 @default.
- W2091838071 cites W1986337203 @default.
- W2091838071 cites W1997064940 @default.
- W2091838071 cites W1998666142 @default.
- W2091838071 cites W2005568288 @default.
- W2091838071 cites W2005607229 @default.
- W2091838071 cites W2017854357 @default.
- W2091838071 cites W2018038850 @default.
- W2091838071 cites W2026813843 @default.
- W2091838071 cites W2046193812 @default.
- W2091838071 cites W2050634031 @default.
- W2091838071 cites W2062179362 @default.
- W2091838071 cites W2077121489 @default.
- W2091838071 cites W2097886755 @default.
- W2091838071 cites W2116137883 @default.
- W2091838071 cites W2117054496 @default.
- W2091838071 cites W2138802593 @default.
- W2091838071 cites W2139749152 @default.
- W2091838071 cites W2141530543 @default.
- W2091838071 cites W2145072668 @default.
- W2091838071 cites W2154771406 @default.
- W2091838071 cites W2158925111 @default.
- W2091838071 cites W2163136815 @default.
- W2091838071 cites W2168874401 @default.
- W2091838071 cites W4254808056 @default.
- W2091838071 doi "https://doi.org/10.1016/j.vetmic.2008.01.008" @default.
- W2091838071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18313237" @default.
- W2091838071 hasPublicationYear "2008" @default.
- W2091838071 type Work @default.
- W2091838071 sameAs 2091838071 @default.
- W2091838071 citedByCount "19" @default.
- W2091838071 countsByYear W20918380712012 @default.
- W2091838071 countsByYear W20918380712013 @default.
- W2091838071 countsByYear W20918380712014 @default.
- W2091838071 countsByYear W20918380712015 @default.
- W2091838071 countsByYear W20918380712016 @default.
- W2091838071 countsByYear W20918380712020 @default.
- W2091838071 countsByYear W20918380712021 @default.
- W2091838071 countsByYear W20918380712022 @default.
- W2091838071 countsByYear W20918380712023 @default.
- W2091838071 crossrefType "journal-article" @default.
- W2091838071 hasAuthorship W2091838071A5005185558 @default.
- W2091838071 hasAuthorship W2091838071A5009331769 @default.
- W2091838071 hasAuthorship W2091838071A5011475425 @default.
- W2091838071 hasAuthorship W2091838071A5027655370 @default.
- W2091838071 hasAuthorship W2091838071A5046473514 @default.
- W2091838071 hasAuthorship W2091838071A5046833493 @default.
- W2091838071 hasAuthorship W2091838071A5049299884 @default.
- W2091838071 hasBestOaLocation W20918380712 @default.
- W2091838071 hasConcept C101762097 @default.
- W2091838071 hasConcept C10389963 @default.
- W2091838071 hasConcept C104317684 @default.
- W2091838071 hasConcept C143065580 @default.
- W2091838071 hasConcept C150194340 @default.
- W2091838071 hasConcept C159047783 @default.
- W2091838071 hasConcept C22744801 @default.
- W2091838071 hasConcept C2777712861 @default.
- W2091838071 hasConcept C2778910516 @default.
- W2091838071 hasConcept C2779574690 @default.
- W2091838071 hasConcept C2779607309 @default.
- W2091838071 hasConcept C2780115692 @default.
- W2091838071 hasConcept C2781065037 @default.
- W2091838071 hasConcept C523546767 @default.
- W2091838071 hasConcept C54355233 @default.
- W2091838071 hasConcept C54602769 @default.
- W2091838071 hasConcept C547475151 @default.
- W2091838071 hasConcept C60987743 @default.
- W2091838071 hasConcept C86803240 @default.
- W2091838071 hasConcept C8891405 @default.
- W2091838071 hasConcept C89423630 @default.
- W2091838071 hasConceptScore W2091838071C101762097 @default.
- W2091838071 hasConceptScore W2091838071C10389963 @default.
- W2091838071 hasConceptScore W2091838071C104317684 @default.
- W2091838071 hasConceptScore W2091838071C143065580 @default.
- W2091838071 hasConceptScore W2091838071C150194340 @default.
- W2091838071 hasConceptScore W2091838071C159047783 @default.
- W2091838071 hasConceptScore W2091838071C22744801 @default.
- W2091838071 hasConceptScore W2091838071C2777712861 @default.
- W2091838071 hasConceptScore W2091838071C2778910516 @default.
- W2091838071 hasConceptScore W2091838071C2779574690 @default.
- W2091838071 hasConceptScore W2091838071C2779607309 @default.
- W2091838071 hasConceptScore W2091838071C2780115692 @default.