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• W2091843886 abstract "De novo protein design offers a unique means to test and advance our understanding of how proteins fold. However, most current design methods are native structure eccentric and folding kinetics has rarely been considered in the design process. Here, we show that a de novo designed mini-protein DS119, which folds into a βαβ structure, exhibits unusually slow and concentration-dependent folding kinetics. For example, the folding time for 50 μM of DS119 was estimated to be ∼2 s. Stopped-flow fluorescence resonance energy transfer experiments further suggested that its folding was likely facilitated by a transient dimerization process. Taken together, these results highlight the need for consideration of the entire folding energy landscape in de novo protein design and provide evidence suggesting nonnative interactions can play a key role in protein folding." @default.
• W2091843886 created "2016-06-24" @default.
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• W2091843886 date "2013-11-01" @default.
• W2091843886 modified "2023-10-17" @default.
• W2091843886 title "Slow and Bimolecular Folding of a De Novo Designed Monomeric Protein DS119" @default.
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• W2091843886 doi "https://doi.org/10.1016/j.bpj.2013.09.014" @default.
• W2091843886 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3824644" @default.
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