FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091846875> ?p ?o ?g. }

• W2091846875 endingPage "1083" @default.
• W2091846875 startingPage "1077" @default.
• W2091846875 abstract "Zonisamide is an antiepileptic drug widely used to treat seizures worldwide. In addition to epilepsy, zonisamide may have beneficial efficacy in various neurological or psychiatric diseases. This article reviews the structure, mechanism of action, pharmacokinetics and possible antiparkinsonian action of zonisamide. A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan provided data suggesting that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson's disease (PD). Zonisamide may be effective in reducing the duration of 'off' time in patients with PD treated with L-DOPA. The therapeutic doses of zonisamide for the treatment of PD are 50-100 mg/day, considerably lower than those for the treatment of epilepsy (200-400 mg/day). It is expected that zonisamide will be safe and tolerated in patients with PD, as it has been used as an antiepileptic for more than 15 years; however, further studies are required to evaluate its safety and tolerability in the treatment of PD. The pharmacological mechanisms of the beneficial actions of zonisamide in PD remain unclear. Various hypotheses have been proposed, but the supporting data are not yet sufficient to draw any conclusions. Further basic research is required to advance our understanding of the antiparkinsonian mechanism of zonisamide." @default.
• W2091846875 created "2016-06-24" @default.
• W2091846875 creator A5066835194 @default.
• W2091846875 date "2007-09-01" @default.
• W2091846875 modified "2023-10-01" @default.
• W2091846875 title "Zonisamide for the treatment of Parkinson’s disease" @default.
• W2091846875 cites W1977786518 @default.
• W2091846875 cites W1988400098 @default.
• W2091846875 cites W1989836839 @default.
• W2091846875 cites W1999328319 @default.
• W2091846875 cites W2002255067 @default.
• W2091846875 cites W2006433347 @default.
• W2091846875 cites W2018343495 @default.
• W2091846875 cites W2018560973 @default.
• W2091846875 cites W2022264559 @default.
• W2091846875 cites W2026052382 @default.
• W2091846875 cites W2032966276 @default.
• W2091846875 cites W2035384588 @default.
• W2091846875 cites W2037468249 @default.
• W2091846875 cites W2041607476 @default.
• W2091846875 cites W2041715217 @default.
• W2091846875 cites W2043209699 @default.
• W2091846875 cites W2043452239 @default.
• W2091846875 cites W2045698358 @default.
• W2091846875 cites W2052202091 @default.
• W2091846875 cites W2052946879 @default.
• W2091846875 cites W2061645338 @default.
• W2091846875 cites W2068361353 @default.
• W2091846875 cites W2077512250 @default.
• W2091846875 cites W2079496953 @default.
• W2091846875 cites W2082508903 @default.
• W2091846875 cites W2083669656 @default.
• W2091846875 cites W2086655716 @default.
• W2091846875 cites W2089167434 @default.
• W2091846875 cites W2090540550 @default.
• W2091846875 cites W2120935292 @default.
• W2091846875 cites W2134321843 @default.
• W2091846875 cites W2141072116 @default.
• W2091846875 cites W2141311399 @default.
• W2091846875 cites W2142090455 @default.
• W2091846875 cites W2159341874 @default.
• W2091846875 cites W2166234140 @default.
• W2091846875 doi "https://doi.org/10.1586/14737175.7.9.1077" @default.
• W2091846875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17868006" @default.
• W2091846875 hasPublicationYear "2007" @default.
• W2091846875 type Work @default.
• W2091846875 sameAs 2091846875 @default.
• W2091846875 citedByCount "15" @default.
• W2091846875 countsByYear W20918468752012 @default.
• W2091846875 countsByYear W20918468752014 @default.
• W2091846875 countsByYear W20918468752015 @default.
• W2091846875 countsByYear W20918468752016 @default.
• W2091846875 countsByYear W20918468752017 @default.
• W2091846875 countsByYear W20918468752020 @default.
• W2091846875 countsByYear W20918468752022 @default.
• W2091846875 crossrefType "journal-article" @default.
• W2091846875 hasAuthorship W2091846875A5066835194 @default.
• W2091846875 hasConcept C118552586 @default.
• W2091846875 hasConcept C126322002 @default.
• W2091846875 hasConcept C197934379 @default.
• W2091846875 hasConcept C2777112843 @default.
• W2091846875 hasConcept C2777138316 @default.
• W2091846875 hasConcept C2777683783 @default.
• W2091846875 hasConcept C2778186239 @default.
• W2091846875 hasConcept C2778375690 @default.
• W2091846875 hasConcept C2778781522 @default.
• W2091846875 hasConcept C2779134260 @default.
• W2091846875 hasConcept C2779734285 @default.
• W2091846875 hasConcept C2780783007 @default.
• W2091846875 hasConcept C42219234 @default.
• W2091846875 hasConcept C71924100 @default.
• W2091846875 hasConcept C98274493 @default.
• W2091846875 hasConceptScore W2091846875C118552586 @default.
• W2091846875 hasConceptScore W2091846875C126322002 @default.
• W2091846875 hasConceptScore W2091846875C197934379 @default.
• W2091846875 hasConceptScore W2091846875C2777112843 @default.
• W2091846875 hasConceptScore W2091846875C2777138316 @default.
• W2091846875 hasConceptScore W2091846875C2777683783 @default.
• W2091846875 hasConceptScore W2091846875C2778186239 @default.
• W2091846875 hasConceptScore W2091846875C2778375690 @default.
• W2091846875 hasConceptScore W2091846875C2778781522 @default.
• W2091846875 hasConceptScore W2091846875C2779134260 @default.
• W2091846875 hasConceptScore W2091846875C2779734285 @default.
• W2091846875 hasConceptScore W2091846875C2780783007 @default.
• W2091846875 hasConceptScore W2091846875C42219234 @default.
• W2091846875 hasConceptScore W2091846875C71924100 @default.
• W2091846875 hasConceptScore W2091846875C98274493 @default.
• W2091846875 hasIssue "9" @default.
• W2091846875 hasLocation W20918468751 @default.
• W2091846875 hasLocation W20918468752 @default.
• W2091846875 hasOpenAccess W2091846875 @default.
• W2091846875 hasPrimaryLocation W20918468751 @default.
• W2091846875 hasRelatedWork W2011034909 @default.
• W2091846875 hasRelatedWork W2023356695 @default.
• W2091846875 hasRelatedWork W2076881486 @default.
• W2091846875 hasRelatedWork W2077441406 @default.
• W2091846875 hasRelatedWork W2106204096 @default.
• W2091846875 hasRelatedWork W2110531075 @default.

• next