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- W2091856713 abstract "The dopamine transporter is elevated in adults with attention deficit hyperactivity disorder (ADHD) compared with healthy controls [Lancet 354 (1999) 2132]. The findings have been confirmed by others in a different population using a different probe for the dopamine transporter. Notwithstanding the need to confirm these findings in a multi-center trial, several hypotheses are presented to account for these observations. A premise that elevated transporter levels result from medication is not supported by current data. Other possibilities, including hypertrophy of dopamine neuronal terminals in the striatum, dysfunctional regulation of dopamine or dopamine receptors, or anomalies in the dopamine transporter gene are presented as hypotheses. The feasibility of exploring these mechanisms in animal models or in human subjects is explored." @default.
- W2091856713 created "2016-06-24" @default.
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- W2091856713 date "2002-03-01" @default.
- W2091856713 modified "2023-10-13" @default.
- W2091856713 title "The dopamine transporter: relevance to attention deficit hyperactivity disorder (ADHD)" @default.
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- W2091856713 doi "https://doi.org/10.1016/s0166-4328(01)00439-9" @default.
- W2091856713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11864718" @default.
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