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• W2091859039 abstract "Abstract Drugs which decrease the synthesis of GABA by inhibition of glutamic acid decarboxylase are invariably convulsant. Correlations of whole brain GABA concentrations with convulsant activity may prove misleading, due to a variety of factors. Thus we have compared the time course of changes in regional GABA concentrations in the rat brain after five GAD inhibitors and related such changes to the pattern of seizure activity produced. L-allylglycine (130 mg/kg) and methyldithiocarbazinate (11 mg/kg) produce similar widespread decreases in GABA. GABA decreases show more regional variation, with a rapid fall in the pons-medulla and a slower decrease in striatum and frontal cortex after isoniazid (250 mg/kg). Small decreases in GABA are localised to the cerebellum, pons-medulla, posterior cortex and hypothalamus after thiosemicarbazide (25 mg/kg). GABA decreases are limited to the cerebellum and pons-medulla after D-allylglycine (425 mg/kg)." @default.
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• W2091859039 date "1980-01-01" @default.
• W2091859039 modified "2023-09-27" @default.
• W2091859039 title "GABA and seizures induced by inhibitors of glutamic acid decarboxylase" @default.
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• W2091859039 doi "https://doi.org/10.1016/0361-9230(80)90099-4" @default.
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