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- W2091859629 abstract "Traditional use of Valeriana officinalis L. suggests sleep promoting properties, yet contemporary observations in clinical trials and rodent models using the extract and isolated compounds are contradictory [1,2]. We evaluated locomotor activity and body temperature of mice using telemetry to obtain evidence of sleep promoting effects. This method provides a reduced variable environment which improves upon previous methodologies. A 70% ethanolic extract of Valeriana officinalis root (250, 500, and 1000mg/kg) was administered orally and data recorded for 180 minutes thereafter in male C57BL/6J mice. Oral administration of valerian extract had no effect on locomotor activity and body temperature compared to vehicle. Zolpidem (5mg/kg, positive control) significantly decreased locomotor activity by 57% (activity counts after 30min; control: 492.1±41.8, zolpidem: 212.6±44.2; p<0.001) and body temperature by 0.57°C (ΔTmax at 18 minutes, control: 36.53±0.12°C, zolpidem: 35.96±0.13°C; p<0.01) whereas caffeine (5mg/kg, negative control) induced an increase in activity of 47% (activity counts after 30 minutes; control: 492.1±41.8, caffeine: 725.1±76.4; p<0.01) without affecting body temperature. In conclusion, telemetry is a simple, adequate method for the specific measurement of sleep promoting effects. The extract showed no significant difference to vehicle; yet, further studies on single compounds may help substantiate the use of Valeriana officinalis as insomnia treatment." @default.
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- W2091859629 date "2009-07-01" @default.
- W2091859629 modified "2023-09-27" @default.
- W2091859629 title "Comparative effects of a valerian extract and single compounds on sleep and body temperature in mice evaluated by telemetry" @default.
- W2091859629 doi "https://doi.org/10.1055/s-0029-1234834" @default.
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