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• W2091867711 abstract "Background: In the most prevalent LQT1 form of inherited long QT syndrome symptoms often occur during abrupt physical or emotional stress. Sympathetic stimulation aggravates repolarization abnormalities in experimental LQT1 models. We hypothesized that autonomic function tests might reveal the abnormal repolarization in asymptomatic LQT1 patients. Methods: We measured heart rates (HRs) and QT intervals in nine asymptomatic carriers of a C‐terminal KCNQ1 mutation and 8 unaffected healthy subjects using an approach of global QT values derived from 28 simultaneous electrocardiographic leads on beat‐to‐beat base during Valsalva maneuver, mental stress, sustained handgrip, and light supine exercise. Results: LQT1 patients exhibited impaired shortening of both QTpeak and QTend intervals during autonomic interventions but exaggerated lengthening of the intervals—a QT overshoot—during the recovery phases. The number of tests with a QT overshoot was 2.4 ± 1.7 in LQT1 patients and 0.8 ± 0.7 in unaffected subjects (P = 0.02). Valsalva strain prolonged T wave peak to T wave end interval (TPE) in LQT1 but not in unaffected patients. LQT1 patients showed diminished HR acceleration in response to adrenergic challenge whereas HR responses to vagal stimuli were similar in both groups. Conclusions: Standard cardiovascular autonomic provocations induce a QT interval overshoot during recovery in asymptomatic KCNQ1 mutation carriers. Valsalva maneuver causes an exaggerated fluctuation of QT and TPE intervals partly explaining the occurrence of cardiac events during abrupt bursts of autonomic activity in LQT1 patients." @default.
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• W2091867711 date "2006-10-01" @default.
• W2091867711 modified "2023-10-15" @default.
• W2091867711 title "Ventricular Repolarization and Heart Rate Responses During Cardiovascular Autonomic Function Testing in LQT1 Subtype of Long QT Syndrome" @default.
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• W2091867711 doi "https://doi.org/10.1111/j.1540-8159.2006.00506.x" @default.
• W2091867711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17038145" @default.
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