FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091877541> ?p ?o ?g. }

• W2091877541 endingPage "598" @default.
• W2091877541 startingPage "589" @default.
• W2091877541 abstract "Both [ 3H]clonidine and [ 3H]idazoxan bind to α2 adrenoceptors. The former also labels imidazoline receptors, and the latter non-adrenergic idazoxan binding sites. In order to investigate whether the imidazoline receptors and non-adrenergic idazoxan binding sites are identical, we compared the binding characteristics of [3H]clonidine and [ 3H]idazoxan to these sites by radioligand binding experiments on ultra-thin slices and homogenates of human striatum. A good correlation was found between the effect of different ions on the binding characteristics of [3H]clonidine and [3H]idazoxan, and the affinities of most competing drugs. However, clonidine and rilmenidine displayed a 100- and 10-fold lower affinity, respectively, for the idazoxan binding sites than for the imidazoline receptors. Autoradiography with [3H]clonidine showed that high densities of imidazoline receptors were present in the striatum, pallidum, gyrus dentatus of the hippocampus, amygdala, and substantia nigra. Moderate densities were found throughout the cerebral cortex, thalamus and several brainstem nuclei including the nucleus olivarius inferior. Low densities were seen in the cerebellum, spinal cord and pituitary gland. As for the non-adrenergic sites labelled by [3H]idazoxan, the imidazoline receptors can be found in all major brain areas examined. However, there are some striking differences between the concentrations of imidazoline receptors and non-adrenergic idazoxan binding sites in certain brain regions. To reconcile distribution and pharmacologic data, we propose that imidazoline receptors and non-adrenergic idazoxan binding sites represent different proteins or protein complexes and that at least in the nucleus reticularis lateralis and the striatum, imidazoline receptors and non-adrenergic idazoxan binding sites may be physically associated. The regional distribution of α2 adrenoceptors within the human CNS was determined by quantitative autoradiography with [3H]RX821002. The highest densities of α2 adrenoceptors were found in the cerebral and cerebellar cortex, and certain regions in the medulla oblongata (floor of the IV ventricle, reticular formation, hypoglossal nucleus and nucleus olivarius inferior). No α2 adrenoceptors were detected in the pituitary gland. There exists no relationship between the distribution pattern of imidazoline receptors and α2 adrenoceptors, indicating that these binding sites are independent from each other." @default.
• W2091877541 created "2016-06-24" @default.
• W2091877541 creator A5016565307 @default.
• W2091877541 creator A5032939230 @default.
• W2091877541 creator A5039175304 @default.
• W2091877541 creator A5053985196 @default.
• W2091877541 creator A5065113357 @default.
• W2091877541 creator A5086785993 @default.
• W2091877541 date "1994-04-01" @default.
• W2091877541 modified "2023-10-18" @default.
• W2091877541 title "Imidazoline receptors, non-adrenergic idazoxan binding sites and α2-adrenoceptors in the human central nervous system" @default.
• W2091877541 cites W1547548853 @default.
• W2091877541 cites W1590338480 @default.
• W2091877541 cites W1769875108 @default.
• W2091877541 cites W1968056243 @default.
• W2091877541 cites W1974106083 @default.
• W2091877541 cites W1978574384 @default.
• W2091877541 cites W1981321734 @default.
• W2091877541 cites W1997946659 @default.
• W2091877541 cites W1999634188 @default.
• W2091877541 cites W1999691892 @default.
• W2091877541 cites W2013947594 @default.
• W2091877541 cites W2014993960 @default.
• W2091877541 cites W2017736705 @default.
• W2091877541 cites W2023775324 @default.
• W2091877541 cites W2032996897 @default.
• W2091877541 cites W2033927165 @default.
• W2091877541 cites W2035032826 @default.
• W2091877541 cites W2036199324 @default.
• W2091877541 cites W2040015508 @default.
• W2091877541 cites W2043813981 @default.
• W2091877541 cites W2046919916 @default.
• W2091877541 cites W2047250424 @default.
• W2091877541 cites W2048128191 @default.
• W2091877541 cites W2056106141 @default.
• W2091877541 cites W2059625918 @default.
• W2091877541 cites W2065845925 @default.
• W2091877541 cites W2070396511 @default.
• W2091877541 cites W2072431227 @default.
• W2091877541 cites W2079208046 @default.
• W2091877541 cites W2082808024 @default.
• W2091877541 cites W2086149148 @default.
• W2091877541 cites W2089540647 @default.
• W2091877541 cites W2117871749 @default.
• W2091877541 cites W4293247451 @default.
• W2091877541 doi "https://doi.org/10.1016/0306-4522(94)90179-1" @default.
• W2091877541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8008210" @default.
• W2091877541 hasPublicationYear "1994" @default.
• W2091877541 type Work @default.
• W2091877541 sameAs 2091877541 @default.
• W2091877541 citedByCount "149" @default.
• W2091877541 countsByYear W20918775412012 @default.
• W2091877541 countsByYear W20918775412013 @default.
• W2091877541 countsByYear W20918775412014 @default.
• W2091877541 countsByYear W20918775412015 @default.
• W2091877541 countsByYear W20918775412016 @default.
• W2091877541 countsByYear W20918775412017 @default.
• W2091877541 countsByYear W20918775412018 @default.
• W2091877541 countsByYear W20918775412019 @default.
• W2091877541 countsByYear W20918775412020 @default.
• W2091877541 countsByYear W20918775412021 @default.
• W2091877541 countsByYear W20918775412022 @default.
• W2091877541 countsByYear W20918775412023 @default.
• W2091877541 crossrefType "journal-article" @default.
• W2091877541 hasAuthorship W2091877541A5016565307 @default.
• W2091877541 hasAuthorship W2091877541A5032939230 @default.
• W2091877541 hasAuthorship W2091877541A5039175304 @default.
• W2091877541 hasAuthorship W2091877541A5053985196 @default.
• W2091877541 hasAuthorship W2091877541A5065113357 @default.
• W2091877541 hasAuthorship W2091877541A5086785993 @default.
• W2091877541 hasConcept C123605464 @default.
• W2091877541 hasConcept C126322002 @default.
• W2091877541 hasConcept C134018914 @default.
• W2091877541 hasConcept C170493617 @default.
• W2091877541 hasConcept C185592680 @default.
• W2091877541 hasConcept C2776885963 @default.
• W2091877541 hasConcept C2777014715 @default.
• W2091877541 hasConcept C2777468819 @default.
• W2091877541 hasConcept C2778399450 @default.
• W2091877541 hasConcept C2778438532 @default.
• W2091877541 hasConcept C2778938600 @default.
• W2091877541 hasConcept C2780062018 @default.
• W2091877541 hasConcept C2780307058 @default.
• W2091877541 hasConcept C2780648677 @default.
• W2091877541 hasConcept C2780939551 @default.
• W2091877541 hasConcept C2781448169 @default.
• W2091877541 hasConcept C40465926 @default.
• W2091877541 hasConcept C513476851 @default.
• W2091877541 hasConcept C515207424 @default.
• W2091877541 hasConcept C55493867 @default.
• W2091877541 hasConcept C58732023 @default.
• W2091877541 hasConcept C71924100 @default.
• W2091877541 hasConcept C86803240 @default.
• W2091877541 hasConceptScore W2091877541C123605464 @default.
• W2091877541 hasConceptScore W2091877541C126322002 @default.
• W2091877541 hasConceptScore W2091877541C134018914 @default.
• W2091877541 hasConceptScore W2091877541C170493617 @default.
• W2091877541 hasConceptScore W2091877541C185592680 @default.

• next