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- W2091878540 abstract "Although intervertebral disc herniation is a well-known disease in dogs, pain management for this condition has remained a challenge. The goal of the present study is to address the lack of information regarding the innervation of anatomical structures within the canine vertebral canal. Immunolabeling was performed with antibodies against protein gene product 9.5, Tuj-1 (neuron-specific class III β-tubulin), calcitonin gene-related peptide, and neuropeptide Y in combination with the lectin from Lycopersicon esculentum as a marker for blood vessels. Staining was indicative of both sensory and sympathetic fibers. Innervation density was the highest in lateral areas, intermediate in dorsal areas, and the lowest in ventral areas. In the dorsal longitudinal ligament (DLL), the highest innervation density was observed in the lateral regions. Innervation was lower at mid-vertebral levels than at intervertebral levels. The presence of sensory and sympathetic fibers in the canine dura and DLL suggests that pain may originate from both these structures. Due to these regional differences in sensory innervation patterns, trauma to intervertebral DLL and lateral dura is expected to be particularly painful. The results ought to provide a better basis for the assessment of medicinal and surgical procedures." @default.
- W2091878540 created "2016-06-24" @default.
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- W2091878540 creator A5068558310 @default.
- W2091878540 creator A5071351635 @default.
- W2091878540 date "2014-04-20" @default.
- W2091878540 modified "2023-09-24" @default.
- W2091878540 title "Sensory innervation of the dorsal longitudinal ligament and the meninges in the lumbar spine of the dog" @default.
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- W2091878540 doi "https://doi.org/10.1007/s00418-014-1218-x" @default.
- W2091878540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24748503" @default.
- W2091878540 hasPublicationYear "2014" @default.
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