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- W2091882928 abstract "✓ Subarachnoid hemorrhage was produced in monkeys by injecting fresh arterial blood. Serial angiographic studies of the basilar artery then showed vasospasm, occurring as a biphasic response similar to that seen following subarachnoid hemorrhage in man. Papaverine had previously been found to be the most potent vasodilator for topical use to release spasm resulting from experimentally induced subarachnoid hemorrhage. This drug was therefore administered, in various dilutions, as a slow infusion into the subarachnoid space of these monkeys. In a concentration of 0.03%, papaverine proved to be effective in reducing the vasospasm without toxicity." @default.
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- W2091882928 date "1973-01-01" @default.
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- W2091882928 title "Observations on the effects of intrathecal papaverine in experimental vasospasm" @default.
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- W2091882928 doi "https://doi.org/10.3171/jns.1973.38.1.0020" @default.
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