Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091885093> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2091885093 endingPage "99" @default.
- W2091885093 startingPage "96" @default.
- W2091885093 abstract "Multiple-active anthelmintic formulations (combinations of anthelmintics with a similar spectrum of activity and different mechanisms of action and resistance) are widely available in several regions of the world for the control of sheep nematodes. There are two main justifications for the use of such combinations: (i) to enable the effective control of nematodes in the presence of single or multiple drug resistance and (ii) to slow development of resistance to the component anthelmintic classes. Computer model simulations of sheep nematode populations indicate that the ability of combinations to slow development of resistance is maximised if certain prerequisite criteria are met, the most important of which appear to concern the opportunity for survival of susceptible nematodes in refugia and the pre-existing levels of resistance to each of the anthelmintics in the combination. The question then becomes whether these criteria are likely to be fulfilled under field conditions. Concerns include the potential to select for resistance to multiple anthelmintic classes concurrently if there are insufficient parasites in refugia, the potential for shared mechanisms of resistance between chemical classes of anthelmintics, the need for further empirical validation of computer simulations, the pre-existing frequency of resistance alleles which may be too high on some farms to warrant introduction of certain combinations and the potential encouragement of farmers to prepare their own mixtures and/or neglect other management principles for sustainable parasite control. In conclusion, multiple-active formulations can play an important role in resistance management. However, they are not a panacea and should always be used in accordance with contemporary principles for sustainable anthelmintic use." @default.
- W2091885093 created "2016-06-24" @default.
- W2091885093 creator A5063629560 @default.
- W2091885093 date "2013-03-01" @default.
- W2091885093 modified "2023-09-30" @default.
- W2091885093 title "Multiple-active anthelmintic formulations: Friend or foe in sustainable parasite control?" @default.
- W2091885093 cites W1916351602 @default.
- W2091885093 cites W1972861566 @default.
- W2091885093 cites W1988601511 @default.
- W2091885093 cites W1990372039 @default.
- W2091885093 cites W1997348211 @default.
- W2091885093 cites W1999754905 @default.
- W2091885093 cites W2016331400 @default.
- W2091885093 cites W2021071200 @default.
- W2091885093 cites W2025517463 @default.
- W2091885093 cites W2028410321 @default.
- W2091885093 cites W2050140084 @default.
- W2091885093 cites W2053074214 @default.
- W2091885093 cites W2053640235 @default.
- W2091885093 cites W2063013012 @default.
- W2091885093 cites W2064132217 @default.
- W2091885093 cites W2082016938 @default.
- W2091885093 cites W2082443443 @default.
- W2091885093 cites W2082461833 @default.
- W2091885093 cites W2084734444 @default.
- W2091885093 cites W2087253029 @default.
- W2091885093 cites W2093803181 @default.
- W2091885093 cites W2131430628 @default.
- W2091885093 cites W2161139119 @default.
- W2091885093 cites W4248675444 @default.
- W2091885093 doi "https://doi.org/10.1016/j.smallrumres.2012.11.012" @default.
- W2091885093 hasPublicationYear "2013" @default.
- W2091885093 type Work @default.
- W2091885093 sameAs 2091885093 @default.
- W2091885093 citedByCount "9" @default.
- W2091885093 countsByYear W20918850932015 @default.
- W2091885093 countsByYear W20918850932016 @default.
- W2091885093 countsByYear W20918850932017 @default.
- W2091885093 countsByYear W20918850932018 @default.
- W2091885093 countsByYear W20918850932022 @default.
- W2091885093 countsByYear W20918850932023 @default.
- W2091885093 crossrefType "journal-article" @default.
- W2091885093 hasAuthorship W2091885093A5063629560 @default.
- W2091885093 hasConcept C112930515 @default.
- W2091885093 hasConcept C118552586 @default.
- W2091885093 hasConcept C144133560 @default.
- W2091885093 hasConcept C150903083 @default.
- W2091885093 hasConcept C15744967 @default.
- W2091885093 hasConcept C18903297 @default.
- W2091885093 hasConcept C2776289891 @default.
- W2091885093 hasConcept C2776908094 @default.
- W2091885093 hasConcept C57473165 @default.
- W2091885093 hasConcept C86803240 @default.
- W2091885093 hasConceptScore W2091885093C112930515 @default.
- W2091885093 hasConceptScore W2091885093C118552586 @default.
- W2091885093 hasConceptScore W2091885093C144133560 @default.
- W2091885093 hasConceptScore W2091885093C150903083 @default.
- W2091885093 hasConceptScore W2091885093C15744967 @default.
- W2091885093 hasConceptScore W2091885093C18903297 @default.
- W2091885093 hasConceptScore W2091885093C2776289891 @default.
- W2091885093 hasConceptScore W2091885093C2776908094 @default.
- W2091885093 hasConceptScore W2091885093C57473165 @default.
- W2091885093 hasConceptScore W2091885093C86803240 @default.
- W2091885093 hasIssue "2-3" @default.
- W2091885093 hasLocation W20918850931 @default.
- W2091885093 hasOpenAccess W2091885093 @default.
- W2091885093 hasPrimaryLocation W20918850931 @default.
- W2091885093 hasRelatedWork W1840978486 @default.
- W2091885093 hasRelatedWork W1990733047 @default.
- W2091885093 hasRelatedWork W1995745532 @default.
- W2091885093 hasRelatedWork W1999754905 @default.
- W2091885093 hasRelatedWork W2014675170 @default.
- W2091885093 hasRelatedWork W2031224848 @default.
- W2091885093 hasRelatedWork W2082141826 @default.
- W2091885093 hasRelatedWork W2884180638 @default.
- W2091885093 hasRelatedWork W2981682772 @default.
- W2091885093 hasRelatedWork W4210635193 @default.
- W2091885093 hasVolume "110" @default.
- W2091885093 isParatext "false" @default.
- W2091885093 isRetracted "false" @default.
- W2091885093 magId "2091885093" @default.
- W2091885093 workType "article" @default.