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- W2091892056 endingPage "e1003899" @default.
- W2091892056 startingPage "e1003899" @default.
- W2091892056 abstract "It has been suggested that HIV-1 has evolved its set-point virus load to be optimized for transmission. Previous epidemiological models and studies into the heritability of set-point virus load confirm that this mode of adaptation within the human population is feasible. However, during the many cycles of replication between infection of a host and transmission to the next host, HIV-1 is under selection for escape from immune responses, and not transmission. Here we investigate with computational and mathematical models how these two levels of selection, within-host and between-host, are intertwined. We find that when the rate of immune escape is comparable to what has been observed in patients, immune selection within hosts is dominant over selection for transmission. Surprisingly, we do find high values for set-point virus load heritability, and argue that high heritability estimates can be caused by the 'footprints' left by differing hosts' immune systems on the virus." @default.
- W2091892056 created "2016-06-24" @default.
- W2091892056 creator A5023400595 @default.
- W2091892056 creator A5053694044 @default.
- W2091892056 creator A5066880216 @default.
- W2091892056 date "2014-12-18" @default.
- W2091892056 modified "2023-10-16" @default.
- W2091892056 title "Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution" @default.
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- W2091892056 cites W1970963975 @default.
- W2091892056 cites W1987891234 @default.
- W2091892056 cites W2005364009 @default.
- W2091892056 cites W2007445829 @default.
- W2091892056 cites W2009082439 @default.
- W2091892056 cites W2009307527 @default.
- W2091892056 cites W2009784575 @default.
- W2091892056 cites W2010218635 @default.
- W2091892056 cites W2010313660 @default.
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- W2091892056 cites W2019559865 @default.
- W2091892056 cites W2027549739 @default.
- W2091892056 cites W2031754540 @default.
- W2091892056 cites W2032099305 @default.
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- W2091892056 cites W2053002571 @default.
- W2091892056 cites W2053978116 @default.
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- W2091892056 doi "https://doi.org/10.1371/journal.pcbi.1003899" @default.
- W2091892056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4270429" @default.
- W2091892056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25522184" @default.
- W2091892056 hasPublicationYear "2014" @default.
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