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• W2091904512 abstract "Evolution has generated enormous morphological diversity in animals and one of the genetic processes that might have contributed to this is evolution of the cis-regulatory sequences responsible for the temporal and spatial expression of genes regulating embryonic development. This could be particularly relevant to pleiotropic genes with multiple independently acting regulatory modules. Loss or gain of modules enables altered expression without loss of other functions. Here I focus on recent studies correlating differences in morphological traits between related species of Drosophila to changes in cis-regulatory sequences. They show that ancestral regulatory modules have evolved to mediate different transcriptional outputs and suggest that evolution of cis-regulatory sequences might reflect a general mechanism driving evolutionary change. Evolution has generated enormous morphological diversity in animals and one of the genetic processes that might have contributed to this is evolution of the cis-regulatory sequences responsible for the temporal and spatial expression of genes regulating embryonic development. This could be particularly relevant to pleiotropic genes with multiple independently acting regulatory modules. Loss or gain of modules enables altered expression without loss of other functions. Here I focus on recent studies correlating differences in morphological traits between related species of Drosophila to changes in cis-regulatory sequences. They show that ancestral regulatory modules have evolved to mediate different transcriptional outputs and suggest that evolution of cis-regulatory sequences might reflect a general mechanism driving evolutionary change." @default.
• W2091904512 created "2016-06-24" @default.
• W2091904512 creator A5079383716 @default.
• W2091904512 date "2007-07-01" @default.
• W2091904512 modified "2023-09-27" @default.
• W2091904512 title "The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila" @default.
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• W2091904512 doi "https://doi.org/10.1016/j.tig.2007.04.006" @default.
• W2091904512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17499383" @default.
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