Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091908560> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2091908560 endingPage "212" @default.
- W2091908560 startingPage "207" @default.
- W2091908560 abstract "<h2>Abstract</h2> <b>OBJECTIVE:</b> The aim of this study was to determine whether inhibition of nitric oxide synthesis would affect the action of an antiprogesterone to provoke preterm labor. <b>STUDY DESIGN:</b> Pregnant rats were continuously infused with N<sup>G</sup>-nitro-L-arginine methyl ester starting on day 16 of gestation. On day 17 of gestation groups of animals were injected subcutaneously with a single dose of either 3 or 30 mg/kg onapristone; animals were monitored for preterm labor and delivery for up to 48 hours. <b>RESULTS:</b> Significant findings included the following results. (1) Combined treatment with N<sup>G</sup>-nitro-L-arginine methyl ester (50 mg per day) and low-dose onapristone (3 mg/kg) produced preterm labor; >70% of the fetuses were delivered within 27 hours of treatment, whereas <5% of the fetuses were delivered in the animals receiving either of these compounds alone. (2) N<sup>G</sup>-nitro-D-arginine methyl ester (50 mg per day) had no effect. (3) Inhibition of nitric oxide by N<sup>G</sup>-nitro-L-arginine methyl ester also significantly increased the efficacy of high-dose onapristone (30 mg/kg) in preterm labor and delivery. <b>CONCLUSION:</b> Treatment of pregnant rats with a combination of a nitric oxide inhibitor with onapristone significantly potentiated the ability of the antiprogesterone to induce preterm labor. The interaction of nitric oxide and progesterone may be required to maintain pregnancy. (Am J Obstet Gynecol 1996;175:207-12.)" @default.
- W2091908560 created "2016-06-24" @default.
- W2091908560 creator A5001604763 @default.
- W2091908560 creator A5017665929 @default.
- W2091908560 creator A5046471717 @default.
- W2091908560 creator A5076296942 @default.
- W2091908560 creator A5088324465 @default.
- W2091908560 date "1996-07-01" @default.
- W2091908560 modified "2023-10-16" @default.
- W2091908560 title "Preterm birth in rats produced by the synergistic action of a nitric oxide inhibitor (NG-nitro-L-arginine methyl ester) and an antiprogestin (onapristone)" @default.
- W2091908560 cites W1964136106 @default.
- W2091908560 cites W1999853564 @default.
- W2091908560 cites W2001016496 @default.
- W2091908560 cites W2004969828 @default.
- W2091908560 cites W2016507004 @default.
- W2091908560 cites W2017543118 @default.
- W2091908560 cites W2025959352 @default.
- W2091908560 cites W2033979289 @default.
- W2091908560 cites W2069565984 @default.
- W2091908560 cites W2088704507 @default.
- W2091908560 cites W2106153775 @default.
- W2091908560 cites W614906504 @default.
- W2091908560 doi "https://doi.org/10.1016/s0002-9378(96)70276-4" @default.
- W2091908560 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8694053" @default.
- W2091908560 hasPublicationYear "1996" @default.
- W2091908560 type Work @default.
- W2091908560 sameAs 2091908560 @default.
- W2091908560 citedByCount "42" @default.
- W2091908560 countsByYear W20919085602014 @default.
- W2091908560 countsByYear W20919085602015 @default.
- W2091908560 crossrefType "journal-article" @default.
- W2091908560 hasAuthorship W2091908560A5001604763 @default.
- W2091908560 hasAuthorship W2091908560A5017665929 @default.
- W2091908560 hasAuthorship W2091908560A5046471717 @default.
- W2091908560 hasAuthorship W2091908560A5076296942 @default.
- W2091908560 hasAuthorship W2091908560A5088324465 @default.
- W2091908560 hasConcept C126322002 @default.
- W2091908560 hasConcept C134018914 @default.
- W2091908560 hasConcept C170493617 @default.
- W2091908560 hasConcept C172680121 @default.
- W2091908560 hasConcept C178790620 @default.
- W2091908560 hasConcept C185592680 @default.
- W2091908560 hasConcept C2776885963 @default.
- W2091908560 hasConcept C2777468819 @default.
- W2091908560 hasConcept C2777622882 @default.
- W2091908560 hasConcept C2779234561 @default.
- W2091908560 hasConcept C2780263894 @default.
- W2091908560 hasConcept C2780639532 @default.
- W2091908560 hasConcept C46973012 @default.
- W2091908560 hasConcept C515207424 @default.
- W2091908560 hasConcept C519581460 @default.
- W2091908560 hasConcept C54355233 @default.
- W2091908560 hasConcept C55493867 @default.
- W2091908560 hasConcept C71924100 @default.
- W2091908560 hasConcept C86803240 @default.
- W2091908560 hasConcept C98274493 @default.
- W2091908560 hasConceptScore W2091908560C126322002 @default.
- W2091908560 hasConceptScore W2091908560C134018914 @default.
- W2091908560 hasConceptScore W2091908560C170493617 @default.
- W2091908560 hasConceptScore W2091908560C172680121 @default.
- W2091908560 hasConceptScore W2091908560C178790620 @default.
- W2091908560 hasConceptScore W2091908560C185592680 @default.
- W2091908560 hasConceptScore W2091908560C2776885963 @default.
- W2091908560 hasConceptScore W2091908560C2777468819 @default.
- W2091908560 hasConceptScore W2091908560C2777622882 @default.
- W2091908560 hasConceptScore W2091908560C2779234561 @default.
- W2091908560 hasConceptScore W2091908560C2780263894 @default.
- W2091908560 hasConceptScore W2091908560C2780639532 @default.
- W2091908560 hasConceptScore W2091908560C46973012 @default.
- W2091908560 hasConceptScore W2091908560C515207424 @default.
- W2091908560 hasConceptScore W2091908560C519581460 @default.
- W2091908560 hasConceptScore W2091908560C54355233 @default.
- W2091908560 hasConceptScore W2091908560C55493867 @default.
- W2091908560 hasConceptScore W2091908560C71924100 @default.
- W2091908560 hasConceptScore W2091908560C86803240 @default.
- W2091908560 hasConceptScore W2091908560C98274493 @default.
- W2091908560 hasIssue "1" @default.
- W2091908560 hasLocation W20919085601 @default.
- W2091908560 hasLocation W20919085602 @default.
- W2091908560 hasOpenAccess W2091908560 @default.
- W2091908560 hasPrimaryLocation W20919085601 @default.
- W2091908560 hasRelatedWork W1993795923 @default.
- W2091908560 hasRelatedWork W2036644978 @default.
- W2091908560 hasRelatedWork W2039466440 @default.
- W2091908560 hasRelatedWork W2045448786 @default.
- W2091908560 hasRelatedWork W2056539393 @default.
- W2091908560 hasRelatedWork W2060935604 @default.
- W2091908560 hasRelatedWork W2078493089 @default.
- W2091908560 hasRelatedWork W2119286799 @default.
- W2091908560 hasRelatedWork W2131811784 @default.
- W2091908560 hasRelatedWork W2397705441 @default.
- W2091908560 hasVolume "175" @default.
- W2091908560 isParatext "false" @default.
- W2091908560 isRetracted "false" @default.
- W2091908560 magId "2091908560" @default.
- W2091908560 workType "article" @default.