FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091909782> ?p ?o ?g. }

• W2091909782 endingPage "820" @default.
• W2091909782 startingPage "815" @default.
• W2091909782 abstract "The hypothesis that multiple trophic inputs are essential for normal development of transmitter release properties in sympathetic neurons was tested using two supportive agents (excess KCl and phorbol 12,13-dibutyrate which produce marked activation of protein kinase C and also support survival of chick sympathetic neurons in culture) in addition to nerve growth factor, ciliary neurotrophic factor and neurotrophin-3. Basal and electrically evoked (10 pulses at 1 Hz and 10 Hz) release of [(3)H]norepinephrine from neurons supported by nerve growth factor was very high (1.5 to 2% of total [(3)H]norepinephrine content) and relatively insensitive to facilitation by tetraethylammonium as compared to release in neuroeffector organs, and the frequency-release response was negative. In K+-supported neurons, basal [(3)H]norepinephrine release was almost four-fold lower, evoked release was four- to eight-fold lower, the frequency response was flat to positive, and tetraethylammonium increased evoked release up to four-fold. Inclusion of nerve growth factor in culture did not modify the effects of K+ on basal or evoked release, and nerve growth factor plus ciliary neurotrophic factor and/or neurotrophin-3 did not produce the changes observed in K+-supported neurons. Neurons supported by phorbol ester had a low background release, low evoked release, a positive frequency-release response, and 10- to 30-fold facilitation by tetraethylammonium of release evoked by 1 Hz or 1 pulse stimulation. Thus, physiological and pharmacological behavior of transmitter release of sympathetic neurons supported by excess KCl or phorbol ester was very similar to their counterparts growing in the body. Neurons supported by nerve growth factor showed an immediate rise in stimulated [Ca(2)+]i that was three- to five-fold above basal levels with either 1 Hz or 10 Hz stimulation. However, in phorbol supported neurons, [Ca(2)+]i rose gradually to about 1.5 times basal levels during 1 Hz stimulation and increased further with 10Hz stimulation. Tetraethylammonium had little effect on stimulated [Ca(2)+]i in nerve growth factor-supported neurons, but greatly facilitated the stimulated rise in [Ca(2)+]i in phorbol-supporte neurons. The data show that multiple trophic inputs distinct from nerve growth factor, neurotrophin-beta or ciliary neurotrophic factor are required for normal physiological function of sympathetic neurons." @default.
• W2091909782 created "2016-06-24" @default.
• W2091909782 creator A5042264523 @default.
• W2091909782 creator A5047304774 @default.
• W2091909782 creator A5077467792 @default.
• W2091909782 creator A5078080372 @default.
• W2091909782 date "1996-06-01" @default.
• W2091909782 modified "2023-09-25" @default.
• W2091909782 title "Importance of protein kinase C for normal development of transmitter release properties in embryonic chick sympathetic neurons in culture" @default.
• W2091909782 cites W1493682862 @default.
• W2091909782 cites W1967888897 @default.
• W2091909782 cites W1974288850 @default.
• W2091909782 cites W1975691097 @default.
• W2091909782 cites W1980044156 @default.
• W2091909782 cites W1991075544 @default.
• W2091909782 cites W1997956038 @default.
• W2091909782 cites W2036096117 @default.
• W2091909782 cites W2036725530 @default.
• W2091909782 cites W2044647611 @default.
• W2091909782 cites W2053321947 @default.
• W2091909782 cites W2058876252 @default.
• W2091909782 cites W2063937262 @default.
• W2091909782 cites W2065959431 @default.
• W2091909782 cites W2090431253 @default.
• W2091909782 cites W2095312523 @default.
• W2091909782 cites W2108792182 @default.
• W2091909782 cites W2141260882 @default.
• W2091909782 doi "https://doi.org/10.1016/0306-4522(95)00573-0" @default.
• W2091909782 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9157327" @default.
• W2091909782 hasPublicationYear "1996" @default.
• W2091909782 type Work @default.
• W2091909782 sameAs 2091909782 @default.
• W2091909782 citedByCount "3" @default.
• W2091909782 crossrefType "journal-article" @default.
• W2091909782 hasAuthorship W2091909782A5042264523 @default.
• W2091909782 hasAuthorship W2091909782A5047304774 @default.
• W2091909782 hasAuthorship W2091909782A5077467792 @default.
• W2091909782 hasAuthorship W2091909782A5078080372 @default.
• W2091909782 hasConcept C126322002 @default.
• W2091909782 hasConcept C134018914 @default.
• W2091909782 hasConcept C160539049 @default.
• W2091909782 hasConcept C170493617 @default.
• W2091909782 hasConcept C178790620 @default.
• W2091909782 hasConcept C185592680 @default.
• W2091909782 hasConcept C24998067 @default.
• W2091909782 hasConcept C2776885963 @default.
• W2091909782 hasConcept C2778423431 @default.
• W2091909782 hasConcept C2778514916 @default.
• W2091909782 hasConcept C2780763569 @default.
• W2091909782 hasConcept C2781295685 @default.
• W2091909782 hasConcept C2910296299 @default.
• W2091909782 hasConcept C513476851 @default.
• W2091909782 hasConcept C517785266 @default.
• W2091909782 hasConcept C71924100 @default.
• W2091909782 hasConcept C86803240 @default.
• W2091909782 hasConcept C92020748 @default.
• W2091909782 hasConceptScore W2091909782C126322002 @default.
• W2091909782 hasConceptScore W2091909782C134018914 @default.
• W2091909782 hasConceptScore W2091909782C160539049 @default.
• W2091909782 hasConceptScore W2091909782C170493617 @default.
• W2091909782 hasConceptScore W2091909782C178790620 @default.
• W2091909782 hasConceptScore W2091909782C185592680 @default.
• W2091909782 hasConceptScore W2091909782C24998067 @default.
• W2091909782 hasConceptScore W2091909782C2776885963 @default.
• W2091909782 hasConceptScore W2091909782C2778423431 @default.
• W2091909782 hasConceptScore W2091909782C2778514916 @default.
• W2091909782 hasConceptScore W2091909782C2780763569 @default.
• W2091909782 hasConceptScore W2091909782C2781295685 @default.
• W2091909782 hasConceptScore W2091909782C2910296299 @default.
• W2091909782 hasConceptScore W2091909782C513476851 @default.
• W2091909782 hasConceptScore W2091909782C517785266 @default.
• W2091909782 hasConceptScore W2091909782C71924100 @default.
• W2091909782 hasConceptScore W2091909782C86803240 @default.
• W2091909782 hasConceptScore W2091909782C92020748 @default.
• W2091909782 hasIssue "3" @default.
• W2091909782 hasLocation W20919097821 @default.
• W2091909782 hasLocation W20919097822 @default.
• W2091909782 hasOpenAccess W2091909782 @default.
• W2091909782 hasPrimaryLocation W20919097821 @default.
• W2091909782 hasRelatedWork W2012422421 @default.
• W2091909782 hasRelatedWork W2028713882 @default.
• W2091909782 hasRelatedWork W2054992011 @default.
• W2091909782 hasRelatedWork W2064416809 @default.
• W2091909782 hasRelatedWork W2079370219 @default.
• W2091909782 hasRelatedWork W2091909782 @default.
• W2091909782 hasRelatedWork W2130112708 @default.
• W2091909782 hasRelatedWork W2444189278 @default.
• W2091909782 hasRelatedWork W2909476884 @default.
• W2091909782 hasRelatedWork W2092333593 @default.
• W2091909782 hasVolume "72" @default.
• W2091909782 isParatext "false" @default.
• W2091909782 isRetracted "false" @default.
• W2091909782 magId "2091909782" @default.
• W2091909782 workType "article" @default.