FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091912939> ?p ?o ?g. }

• W2091912939 endingPage "568" @default.
• W2091912939 startingPage "559" @default.
• W2091912939 abstract "The identification of potential allergenic proteins is usually done by scanning a database of allergenic proteins and locating known allergens with a high sequence similarity. However, there is no universally accepted cut-off value for sequence similarity to indicate potential IgE cross-reactivity. Further, overall sequence similarity may be less important than discrete areas of similarity in proteins with homologous structure. To identify such areas, we first classified all allergens and their subdomains in the Structural Database of Allergenic Proteins (SDAP, http://fermi.utmb.edu/SDAP/) to their closest protein families as defined in Pfam, and identified conserved physicochemical property motifs characteristic of each group of sequences. Allergens populate only a small subset of all known Pfam families, as all allergenic proteins in SDAP could be grouped to only 130 (of 9318 total) Pfams, and 31 families contain more than four allergens. Conserved physicochemical property motifs for the aligned sequences of the most populated Pfam families were identified with the PCPMer program suite and catalogued in the webserver MotifMate (http://born.utmb.edu/motifmate/summary.php). We also determined specific motifs for allergenic members of a family that could distinguish them from non-allergenic ones. These allergen specific motifs should be most useful in database searches for potential allergens. We found that sequence motifs unique to the allergens in three families (seed storage proteins, Bet v 1, and tropomyosin) overlap with known IgE epitopes, thus providing evidence that our motif based approach can be used to assess the potential allergenicity of novel proteins." @default.
• W2091912939 created "2016-06-24" @default.
• W2091912939 creator A5006473765 @default.
• W2091912939 creator A5011631746 @default.
• W2091912939 creator A5025138239 @default.
• W2091912939 creator A5034853603 @default.
• W2091912939 creator A5043184951 @default.
• W2091912939 date "2009-02-01" @default.
• W2091912939 modified "2023-10-17" @default.
• W2091912939 title "Characteristic motifs for families of allergenic proteins" @default.
• W2091912939 cites W1532202009 @default.
• W2091912939 cites W1579694277 @default.
• W2091912939 cites W1610026461 @default.
• W2091912939 cites W1696185372 @default.
• W2091912939 cites W1805406875 @default.
• W2091912939 cites W1963608069 @default.
• W2091912939 cites W1965525135 @default.
• W2091912939 cites W1970880716 @default.
• W2091912939 cites W1973846182 @default.
• W2091912939 cites W1981031577 @default.
• W2091912939 cites W1996507063 @default.
• W2091912939 cites W1997020941 @default.
• W2091912939 cites W2004789352 @default.
• W2091912939 cites W2008291884 @default.
• W2091912939 cites W2008617182 @default.
• W2091912939 cites W2013141036 @default.
• W2091912939 cites W2015047311 @default.
• W2091912939 cites W2020538616 @default.
• W2091912939 cites W2022714267 @default.
• W2091912939 cites W2022793780 @default.
• W2091912939 cites W2030742559 @default.
• W2091912939 cites W2031854599 @default.
• W2091912939 cites W2032226763 @default.
• W2091912939 cites W2036443097 @default.
• W2091912939 cites W2037263319 @default.
• W2091912939 cites W2046759597 @default.
• W2091912939 cites W2051192721 @default.
• W2091912939 cites W2052290049 @default.
• W2091912939 cites W2053131148 @default.
• W2091912939 cites W2056109773 @default.
• W2091912939 cites W2056421768 @default.
• W2091912939 cites W2056717140 @default.
• W2091912939 cites W2057424219 @default.
• W2091912939 cites W2057442947 @default.
• W2091912939 cites W2058466413 @default.
• W2091912939 cites W2059968756 @default.
• W2091912939 cites W2063380886 @default.
• W2091912939 cites W2064119141 @default.
• W2091912939 cites W2065504830 @default.
• W2091912939 cites W2065726131 @default.
• W2091912939 cites W2072004644 @default.
• W2091912939 cites W2075040473 @default.
• W2091912939 cites W2076422111 @default.
• W2091912939 cites W2077411436 @default.
• W2091912939 cites W2079208358 @default.
• W2091912939 cites W2080523731 @default.
• W2091912939 cites W2086497859 @default.
• W2091912939 cites W2086649823 @default.
• W2091912939 cites W2087173986 @default.
• W2091912939 cites W2091411904 @default.
• W2091912939 cites W2095724872 @default.
• W2091912939 cites W2096255039 @default.
• W2091912939 cites W2098419338 @default.
• W2091912939 cites W2101368598 @default.
• W2091912939 cites W2102023232 @default.
• W2091912939 cites W2104042418 @default.
• W2091912939 cites W2110032853 @default.
• W2091912939 cites W2111876811 @default.
• W2091912939 cites W2112874093 @default.
• W2091912939 cites W2116809392 @default.
• W2091912939 cites W2118268072 @default.
• W2091912939 cites W2118861388 @default.
• W2091912939 cites W2119152270 @default.
• W2091912939 cites W2123994079 @default.
• W2091912939 cites W2125842347 @default.
• W2091912939 cites W2126039077 @default.
• W2091912939 cites W2127341158 @default.
• W2091912939 cites W2132116179 @default.
• W2091912939 cites W2136280642 @default.
• W2091912939 cites W2139091446 @default.
• W2091912939 cites W2141204732 @default.
• W2091912939 cites W2144675355 @default.
• W2091912939 cites W2147354840 @default.
• W2091912939 cites W2152171716 @default.
• W2091912939 cites W2153544727 @default.
• W2091912939 cites W2160354505 @default.
• W2091912939 cites W2160617979 @default.
• W2091912939 cites W2161851240 @default.
• W2091912939 cites W2161851751 @default.
• W2091912939 cites W2162060551 @default.
• W2091912939 cites W2162146384 @default.
• W2091912939 cites W2168365842 @default.
• W2091912939 cites W2168518560 @default.
• W2091912939 cites W2169959116 @default.
• W2091912939 cites W2171772190 @default.
• W2091912939 cites W2058994405 @default.
• W2091912939 doi "https://doi.org/10.1016/j.molimm.2008.07.034" @default.
• W2091912939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2631092" @default.

• next