FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2091918399> ?p ?o ?g. }

• W2091918399 endingPage "212" @default.
• W2091918399 startingPage "203" @default.
• W2091918399 abstract "The role of nitric oxide (NO) in the pathogenesis of viral encephalitis was investigated by using an experimental model of herpes simplex virus type 1 (HSV-1) encephalitis in Lewis rats. The expression of inducible NO synthase (iNOS) mRNA determined by Northern blotting was observed first in the olfactory bulb and the brain stem on day 5 after intranasal inoculation of HSV-1, and thereafter iNOS mRNA was detected in other brain regions, i.e., cerebrum and cerebellum. In various parts of the brain, excessive NO production was identified by electron spin resonance spectroscopy. The temporal and spatial patterns of iNOS expression coincided with those of viral propagation, as demonstrated by polymerase chain reaction for HSV-1 gene expression as well as by the plaque-forming assay. Immunohistochemical study determined that iNOS was localized mainly in monocyte-derived macrophages. Treatment of virus-infected animals with the NOS inhibitor Nω-monomethyl-l-arginine (l-NMMA), but not Nω-monomethyl-d-arginine, significantly ameliorated not only clinical symptoms such as paralysis and seizures but also mortality. Virus yield from brain tissue was not affected by l-NMMA treatment. It is of interest that increased expression of the antioxidant enzyme heme oxygenase-1 was observed in the HSV-1-infected brain; this increased expression was strongly inhibited by l-NMMA treatment. These data suggest that the high level of NO produced by iNOS is a pathogenic factor in HSV-1-induced encephalitis in rats." @default.
• W2091918399 created "2016-06-24" @default.
• W2091918399 creator A5067437840 @default.
• W2091918399 creator A5072183453 @default.
• W2091918399 creator A5080816054 @default.
• W2091918399 date "1999-04-01" @default.
• W2091918399 modified "2023-09-27" @default.
• W2091918399 title "Role of Nitric Oxide in Pathogenesis of Herpes Simplex Virus Encephalitis in Rats" @default.
• W2091918399 cites W1657916452 @default.
• W2091918399 cites W1821918060 @default.
• W2091918399 cites W1897984827 @default.
• W2091918399 cites W1909744463 @default.
• W2091918399 cites W1964646250 @default.
• W2091918399 cites W1966971174 @default.
• W2091918399 cites W1977075125 @default.
• W2091918399 cites W1988015834 @default.
• W2091918399 cites W1997001042 @default.
• W2091918399 cites W1998027005 @default.
• W2091918399 cites W2010273334 @default.
• W2091918399 cites W2011769338 @default.
• W2091918399 cites W2017832190 @default.
• W2091918399 cites W2019489183 @default.
• W2091918399 cites W2034225517 @default.
• W2091918399 cites W2037894687 @default.
• W2091918399 cites W2038733394 @default.
• W2091918399 cites W2039409172 @default.
• W2091918399 cites W2040981816 @default.
• W2091918399 cites W2052234834 @default.
• W2091918399 cites W2055111778 @default.
• W2091918399 cites W2062384458 @default.
• W2091918399 cites W2063680573 @default.
• W2091918399 cites W2068098919 @default.
• W2091918399 cites W2073132923 @default.
• W2091918399 cites W2089677528 @default.
• W2091918399 cites W2090573720 @default.
• W2091918399 cites W2093708814 @default.
• W2091918399 cites W2094764360 @default.
• W2091918399 cites W2118446850 @default.
• W2091918399 cites W2124829361 @default.
• W2091918399 cites W2126624423 @default.
• W2091918399 cites W2138766005 @default.
• W2091918399 cites W2145208713 @default.
• W2091918399 cites W2145530136 @default.
• W2091918399 cites W2152611825 @default.
• W2091918399 cites W2155080698 @default.
• W2091918399 cites W2156041007 @default.
• W2091918399 cites W2167935134 @default.
• W2091918399 cites W2168896761 @default.
• W2091918399 cites W2313326603 @default.
• W2091918399 doi "https://doi.org/10.1006/viro.1999.9610" @default.
• W2091918399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10191185" @default.
• W2091918399 hasPublicationYear "1999" @default.
• W2091918399 type Work @default.
• W2091918399 sameAs 2091918399 @default.
• W2091918399 citedByCount "103" @default.
• W2091918399 countsByYear W20919183992012 @default.
• W2091918399 countsByYear W20919183992013 @default.
• W2091918399 countsByYear W20919183992014 @default.
• W2091918399 countsByYear W20919183992015 @default.
• W2091918399 countsByYear W20919183992016 @default.
• W2091918399 countsByYear W20919183992017 @default.
• W2091918399 countsByYear W20919183992018 @default.
• W2091918399 countsByYear W20919183992019 @default.
• W2091918399 countsByYear W20919183992020 @default.
• W2091918399 countsByYear W20919183992021 @default.
• W2091918399 countsByYear W20919183992022 @default.
• W2091918399 crossrefType "journal-article" @default.
• W2091918399 hasAuthorship W2091918399A5067437840 @default.
• W2091918399 hasAuthorship W2091918399A5072183453 @default.
• W2091918399 hasAuthorship W2091918399A5080816054 @default.
• W2091918399 hasBestOaLocation W20919183991 @default.
• W2091918399 hasConcept C134018914 @default.
• W2091918399 hasConcept C153911025 @default.
• W2091918399 hasConcept C159047783 @default.
• W2091918399 hasConcept C203014093 @default.
• W2091918399 hasConcept C2522874641 @default.
• W2091918399 hasConcept C2776409557 @default.
• W2091918399 hasConcept C2777622882 @default.
• W2091918399 hasConcept C2779141303 @default.
• W2091918399 hasConcept C2779450786 @default.
• W2091918399 hasConcept C2780727368 @default.
• W2091918399 hasConcept C2780942790 @default.
• W2091918399 hasConcept C2781196997 @default.
• W2091918399 hasConcept C519581460 @default.
• W2091918399 hasConcept C83455156 @default.
• W2091918399 hasConcept C86803240 @default.
• W2091918399 hasConceptScore W2091918399C134018914 @default.
• W2091918399 hasConceptScore W2091918399C153911025 @default.
• W2091918399 hasConceptScore W2091918399C159047783 @default.
• W2091918399 hasConceptScore W2091918399C203014093 @default.
• W2091918399 hasConceptScore W2091918399C2522874641 @default.
• W2091918399 hasConceptScore W2091918399C2776409557 @default.
• W2091918399 hasConceptScore W2091918399C2777622882 @default.
• W2091918399 hasConceptScore W2091918399C2779141303 @default.
• W2091918399 hasConceptScore W2091918399C2779450786 @default.
• W2091918399 hasConceptScore W2091918399C2780727368 @default.
• W2091918399 hasConceptScore W2091918399C2780942790 @default.
• W2091918399 hasConceptScore W2091918399C2781196997 @default.

• next